Direct-Acting Antivirals' Safety Profile in Patients with Advanced Liver Cirrhosis with Hepatitis C: A Systematic Review and Meta-Analysis

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dc.contributor.authorKhan, SMen_US
dc.contributor.authorNazmin, Fen_US
dc.contributor.authorRay, Ren_US
dc.contributor.authorHachem, Ren_US
dc.contributor.authorWade, Ben_US
dc.contributor.authorBhinder, MAen_US
dc.contributor.authorChaudhry, MBen_US
dc.contributor.authorSyed, Men_US
dc.contributor.authorKhan, Aen_US
dc.contributor.authorFatima, Een_US
dc.contributor.authorUllah, I.en_US
dc.date.accessioned2024-11-30T08:52:06Z
dc.date.available2024-11-30T08:52:06Z
dc.date.issued2024-06
dc.description.abstractChronic hepatitis C with cirrhosis is treated with direct-acting antibiotics (DAAs). The aim of this study was to investigate the effect of direct-acting antibodies in the treatment of hepatitis C in cirrhosis. It also examines the proportion of drug-related problems, side effects, and mortality. The Cochrane Library and PubMed were thoroughly searched for the required literature. Fifteen articles were extracted for inclusion in this systematic review and meta-analysis. A total of 16 studies were thoroughly screened. The included studies provided a comprehensive picture of the effects of DAA therapy, spanning multiple study designs and sites Our analysis showed that good responses were observed with DAA regimens and that treatment discontinuation was low due to adverse events a stirring that. Few adverse events were reported, but all were mostly uncontrolled to prevent treatment discontinuation or death. In addition, meta-analytic studies on specific outcomes such as encephalopathy, ascites, hepatocellular carcinoma (HCC), adverse events, and death provided quantitative analysis about the safety of DAAs. Research also shows that DAAs have fewer side effects, deaths, and complications than other treatments.en_US
dc.identifier.affiliationsKHSC College of Osteopathic Medicine, Wichita, USAen_US
dc.identifier.affiliationsBronx Care Health System, Bronx, USAen_US
dc.identifier.affiliationsBankura Sammilani Medical College, Bankura, Indiaen_US
dc.identifier.affiliationsSaint James School of Medicine, Illinois, USAen_US
dc.identifier.affiliationsAmerican University of Antigua, New York, USAen_US
dc.identifier.affiliationsCMH Lahore Medical College and Institute of Dentistry, Lahore, Pakistanen_US
dc.identifier.affiliationsCMH Lahore Medical College and Institute of Dentistry, Lahore, Pakistanen_US
dc.identifier.affiliationsFatima Jinnah Medical University, Lahore, Pakistanen_US
dc.identifier.affiliationsKarachi Medical and Dental College, Karachi, Pakistanen_US
dc.identifier.affiliationsAkhtar Saeed Medical and Dental College, Lahore, Pakistanen_US
dc.identifier.affiliationsKhyber Medical College, Peshawar, Pakistan.en_US
dc.identifier.citationKhan SM, Nazmin F, Ray R, Hachem R, Wade B, Bhinder MA, Chaudhry MB, Syed M, Khan A, Fatima E, Ullah I.. Direct-Acting Antivirals' Safety Profile in Patients with Advanced Liver Cirrhosis with Hepatitis C: A Systematic Review and Meta-Analysis. Journal of Advances in Medicine and Medical Research. 2024 Jun; 36(6): 266-281en_US
dc.identifier.issn2456-8899
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/237244
dc.languageenen_US
dc.publisherMs. M. B. Mondalen_US
dc.relation.issuenumber6en_US
dc.relation.volume36en_US
dc.source.urihttps://doi.org/10.9734/jammr/2024/v36i65469en_US
dc.subjectHepatitis Cen_US
dc.subjectdirect-acting antivirals (DAAs)en_US
dc.subjectliver cirrhosisen_US
dc.subjectsystematic reviewen_US
dc.subjectmeta-analysisen_US
dc.subjectsafety profileen_US
dc.subjectadverse eventsen_US
dc.subjecttreatment efficacyen_US
dc.subjectchronic liver diseaseen_US
dc.subjectviral eradicationen_US
dc.titleDirect-Acting Antivirals' Safety Profile in Patients with Advanced Liver Cirrhosis with Hepatitis C: A Systematic Review and Meta-Analysisen_US
dc.typeJournal Articleen_US
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