Aspergillus spp., a versatile cell factory for enzymes and metabolites: Interventions through genome editing

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dc.contributor.authorMadhavan, Aravinden_US
dc.contributor.authorArun, K Ben_US
dc.contributor.authorSindhu, Raveendranen_US
dc.contributor.authorBinod, Parameswaranen_US
dc.contributor.authorAwasthi, Mukesh Kumaren_US
dc.contributor.authorPandey, Ashoken_US
dc.date.accessioned2023-08-09T06:20:52Z
dc.date.available2023-08-09T06:20:52Z
dc.date.issued2022-09
dc.description.abstractAspergillus sp. is widely distributed in nature and plays significant roles in the degradation of lignocellulose biomass and extensively used in bioprocess and fermentation technology and many species are also a generally regarded safe. Many of the Aspergillus species are established cell factories due to their inherent capacity in secreting large number of hydrolytic enzymes. With the advent of next generation genomic technologies and metabolic engineering technologies, the production potential of Aspergillus cell factory has improved over the years. Various genome editing tools has been developed for Aspergillus like engineered nucleases, zinc finger nucleases, TALEN and CRISPR-Cas9 system. Currently, the CRISPR/Cas9-based technique is extensively used to enhance the effectiveness of gene manipulation in model system Aspergillus nidulans and other strains like Aspergillus oryzae, Aspergillus niger and Aspergillus fumigatus. This review describes the recent developments of genome editing technologies in Aspergillus the synthesis of heterologous proteins and secondary metabolites in the Aspergillus species.en_US
dc.identifier.affiliationsRajiv Gandhi Centre for Biotechnology, Jagathy, Thiruvananthapuram-695 014, Kerala, Indiaen_US
dc.identifier.affiliationsSchool of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Kerala, Indiaen_US
dc.identifier.affiliationsDepartment of Life Sciences, CHRIST (Deemed to be University), Bengaluru-560 029, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Food Technology, T K M Institute of Technology, Kollam-691 505, Kerala, Indiaen_US
dc.identifier.affiliationsMicrobial Processes and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Trivandrum-695 019, Kerala, Indiaen_US
dc.identifier.affiliationsCollege of Natural Resources and Environment, Northwest A & F University, Yangling, Shaanxi-712 100, Chinaen_US
dc.identifier.affiliationsCenter for Innovation and Translational Research, CSIR-Indian Institute of Toxicology Research, Lucknow-226 001, Indiaen_US
dc.identifier.affiliationsSustainability cluster, School of engineering, University of Petroleum and Energy Studies, Dehradun-248 007, Uttarakhand, Indiaen_US
dc.identifier.affiliationsCentre for Energy and Environmental Sustainability, Lucknow-226 029, Uttar Pradesh, Indiaen_US
dc.identifier.citationMadhavan Aravind, Arun K B, Sindhu Raveendran, Binod Parameswaran, Awasthi Mukesh Kumar, Pandey Ashok. Aspergillus spp., a versatile cell factory for enzymes and metabolites: Interventions through genome editing. Indian Journal of Experimental Biology. 2022 Sep; 60(9): 647-658en_US
dc.identifier.issn0975-1009
dc.identifier.issn0019-5189
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/222527
dc.languageenen_US
dc.publisherCSIR-NIScPRen_US
dc.relation.issuenumber9en_US
dc.relation.volume60en_US
dc.source.urihttps://doi.org/10.56042/ijeb.v60i09.65635en_US
dc.subjectCRISPRen_US
dc.subjectGenome editingen_US
dc.titleAspergillus spp., a versatile cell factory for enzymes and metabolites: Interventions through genome editingen_US
dc.typeJournal Articleen_US
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