Anti-diabetic activity and safety assessment of Ayurvedic medicine, Jasada bhasma (zinc ash) in rats.

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dc.contributor.authorUmrani, Rinku D
dc.contributor.authorAgrawal, Durgashankar S
dc.contributor.authorPaknikar, Kishore M
dc.date.accessioned2013-11-19T05:55:11Z
dc.date.available2013-11-19T05:55:11Z
dc.date.issued2013-10
dc.description.abstractJasada bhasma (zinc ash) is an extensively used Ayurvedic medicine for treating diabetes mellitus. The present communication presents yet unavailable comprehensive scientific data on its physico-chemical nature vis-à-vis anti-diabetic activity and toxicity profile.Zinc ash prepared by traditional method was found to consist of 200-500 nm sized particles, predominantly zinc oxide with hexagonal wurtzite crystal structure.The effective dose range of zinc ash in oral glucose tolerance tests performed using normoglycemic Wistar rats was found to be 3-30 mg/kg. Subsequently anti-diabetic activity was assessed in streptozotocin induced type 1 and type 2 diabetic rats. Four weeks treatment with zinc ash (1, 3, 10 mg/kg) resulted in improved glucose tolerance (16-19%), lowered blood glucose levels (20-33%) and reduced serum insulin levels (27-32%). Systemic absorption was assessed by single dose pharmacokinetic study where serum zinc levels were found to be elevated (3.5 folds) after oral administration of zinc ash. Acute and sub-acute toxicity tests demonstrated safety of zinc ash up to 300 mg/kg doseie. 100 times the efficacy dose in rats.These findings, the first of their kind, provide concrete scientific evidence that justifies usage of zinc ash in diabetes treatment.en_US
dc.identifier.citationUmrani Rinku D, Agrawal Durgashankar S, Paknikar Kishore M. Anti-diabetic activity and safety assessment of Ayurvedic medicine, Jasada bhasma (zinc ash) in rats. Indian Journal of Experimental Biology. 2013 Oct; 51(10): 811-822.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/149386
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/21445en_US
dc.subjectAyurvedaen_US
dc.subjectDiabetesen_US
dc.subjectJasada bhasmaen_US
dc.subjectPharmacokineticsen_US
dc.subjectRatsen_US
dc.subjectStreptozotocinen_US
dc.subjectToxicityen_US
dc.subjectZinc ashen_US
dc.subject.meshAnimals
dc.subject.meshDiabetes Mellitus, Experimental --chemically induced
dc.subject.meshDiabetes Mellitus, Experimental --drug therapy
dc.subject.meshDose-Response Relationship, Drug
dc.subject.meshFemale
dc.subject.meshHypoglycemic Agents --adverse effects
dc.subject.meshHypoglycemic Agents --therapeutic use
dc.subject.meshMale
dc.subject.meshMedicine, Ayurvedic
dc.subject.meshRats
dc.subject.meshRats, Wistar
dc.subject.meshZinc Oxide --adverse effects
dc.subject.meshZinc Oxide --chemistry
dc.subject.meshZinc Oxide --therapeutic use
dc.titleAnti-diabetic activity and safety assessment of Ayurvedic medicine, Jasada bhasma (zinc ash) in rats.en_US
dc.typeArticleen_US
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