Synthesis, antimicrobial activity and Molecular docking study of some novel isoxazole incorporated benzimidazole derivatives

Simple item page
dc.contributor.authorSharma, Pankaj Kumaren_US
dc.contributor.authorSharma, Chandra Shekharen_US
dc.date.accessioned2024-09-24T08:59:28Z
dc.date.accessioned2024-09-24T11:51:29Z
dc.date.available2024-09-24T08:59:28Z
dc.date.available2024-09-24T11:51:29Z
dc.date.issued2023-12
dc.description.abstractA series of novel isoxazole-incorporated benzimidazole derivatives was synthesized and investigated for antimicrobial activity. The structures of all synthesized compounds were confirmed by means of elemental analysis, infrared spectroscopy (IR), proton nuclear magnetic resonance (1H-NMR), and liquid chromatography-mass spectrometry (LC-MS). All compounds were evaluated for antimicrobial activity cup plate method against Staphylococcus aureus, Bacillus anthracis, Pseudomonas aeruginosa, Escherchia coli, Candida albicans and Aspegillus niger. The 4d, 4f and 4j compounds showed significant activity against gram-positive and gram-negative bacteria. On the basis of the interaction energy criterion, compound 4f showed the best docking interactions equal to 7.0 kcal/mol.en_US
dc.identifier.affiliationsDepartment of Pharmaceutical Chemistry, Bhupal Nobles’ College of Pharmacy, Bhupal Nobles’ University, Udaipur, Rajasthan, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Chemistry, Bhupal Nobles’ College of Pharmacy, Bhupal Nobles’ University, Udaipur, Rajasthan, Indiaen_US
dc.identifier.citationSharma Pankaj Kumar, Sharma Chandra Shekhar . Synthesis, antimicrobial activity and Molecular docking study of some novel isoxazole incorporated benzimidazole derivatives . International Journal of Pharmaceutical Sciences and Drug Research . 2023 Nov; 15(6): 680-687en_US
dc.identifier.issn0975–248X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/231731
dc.languageenen_US
dc.publisherMRI Publication Pvt. Ltd.en_US
dc.relation.issuenumber6en_US
dc.relation.volume15en_US
dc.source.urihttps://doi.org/10.25004/IJPSDR.2023.150601en_US
dc.subjectIsoxazoleen_US
dc.subjectBenzimidazoleen_US
dc.subjectAntimicrobial activityen_US
dc.subjectSynthesisen_US
dc.subjectMolecular dockingen_US
dc.titleSynthesis, antimicrobial activity and Molecular docking study of some novel isoxazole incorporated benzimidazole derivativesen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ijpsdr2023v15n6p680.pdf
Size:
741.53 KB
Format:
Adobe Portable Document Format
Download
Collections
International Journal of Pharmaceutical Sciences and Drug Research