Efficacy of 4-methyl-7-hydroxy coumarin derivatives against vectors Aedes aegypti and Culex quinquefasciatus.
dc.contributor.author | Deshmukh, Madhavi | en_US |
dc.contributor.author | Pawar, Pushpa | en_US |
dc.contributor.author | Joseph, Mary | en_US |
dc.contributor.author | Phalgune, Usha | en_US |
dc.contributor.author | Kashalkar, Rajashree | en_US |
dc.contributor.author | Deshpande, Nirmala R | en_US |
dc.date.accessioned | 2009-05-28T13:40:54Z | |
dc.date.available | 2009-05-28T13:40:54Z | |
dc.date.issued | 2008-11-19 | en_US |
dc.description.abstract | 4-Methyl-7-hydroxy coumarin is considered as a lead molecule as a biopesticide. Its mono bromo and tribromo derivatives were synthesized. Two more derivatives were synthesized by acylation. Compound 1 (3,6,8-tribromo-7-hydroxy-4-methyl-chromen-2-one) was found to be the most potent against IVth instar larvae of C. quinquefasciatus and A. aegypti the LC50 being 1.49 and 2.23 ppm respectively. It showed 100% larval mortality at 25 ppm against A. aegypti and at 10 ppm against C. quinquefasciatus. Compounds 1 and 2 (3,6,8-tribromo-7-hydroxy-4-methyl-chromen-2'-oxo-2H-chromen-7-yl acetate) showed remarkable ovicidal activity. Significant reduction of 80-85% hatching of eggs of both mosquito species was observed at the highest dose of 100 ppm. The hatched larvae showed 100% mortality in the successive instars. Compounds 3 and 4 (3-bromo-7-hydroxy-4-methyl-chromen-2-one and 3-bromo-4-methyl-2'-oxo-2H-chromen-7-yl acetate) showed moderate activity against both mosquito species. | en_US |
dc.description.affiliation | Department of Chemistry, Sir Parshurambhau College, Pune 411 030, India. madhaviarya@rediffmail.com | en_US |
dc.identifier.citation | Deshmukh M, Pawar P, Joseph M, Phalgune U, Kashalkar R, Deshpande NR. Efficacy of 4-methyl-7-hydroxy coumarin derivatives against vectors Aedes aegypti and Culex quinquefasciatus. Indian Journal of Experimental Biology. 2008 Nov; 46(11): 788-92 | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/59728 | |
dc.language.iso | eng | en_US |
dc.source.uri | https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.asp | en_US |
dc.source.uri | https://nopr.niscair.res.in/bitstream/123456789/4650/1/IJEB%2046%2811%29%20788-792.pdf | en_US |
dc.subject.mesh | Aedes --drug effects | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Biological Assay | en_US |
dc.subject.mesh | Chemistry, Pharmaceutical --methods | en_US |
dc.subject.mesh | Culex --drug effects | en_US |
dc.subject.mesh | Drug Design | en_US |
dc.subject.mesh | Drug Evaluation, Preclinical | en_US |
dc.subject.mesh | Hymecromone --administration & dosage | en_US |
dc.subject.mesh | Insecticide Resistance --drug effects | en_US |
dc.subject.mesh | Insecticides --pharmacology | en_US |
dc.subject.mesh | Larva --drug effects | en_US |
dc.subject.mesh | Magnetic Resonance Spectroscopy | en_US |
dc.subject.mesh | Models, Chemical | en_US |
dc.subject.mesh | Mosquito Control | en_US |
dc.subject.mesh | Pesticides --chemistry | en_US |
dc.title | Efficacy of 4-methyl-7-hydroxy coumarin derivatives against vectors Aedes aegypti and Culex quinquefasciatus. | en_US |
dc.type | Journal Article | en_US |
Files
License bundle
1 - 1 of 1