Efficacy of 4-methyl-7-hydroxy coumarin derivatives against vectors Aedes aegypti and Culex quinquefasciatus.

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dc.contributor.authorDeshmukh, Madhavien_US
dc.contributor.authorPawar, Pushpaen_US
dc.contributor.authorJoseph, Maryen_US
dc.contributor.authorPhalgune, Ushaen_US
dc.contributor.authorKashalkar, Rajashreeen_US
dc.contributor.authorDeshpande, Nirmala Ren_US
dc.date.accessioned2009-05-28T13:40:54Z
dc.date.available2009-05-28T13:40:54Z
dc.date.issued2008-11-19en_US
dc.description.abstract4-Methyl-7-hydroxy coumarin is considered as a lead molecule as a biopesticide. Its mono bromo and tribromo derivatives were synthesized. Two more derivatives were synthesized by acylation. Compound 1 (3,6,8-tribromo-7-hydroxy-4-methyl-chromen-2-one) was found to be the most potent against IVth instar larvae of C. quinquefasciatus and A. aegypti the LC50 being 1.49 and 2.23 ppm respectively. It showed 100% larval mortality at 25 ppm against A. aegypti and at 10 ppm against C. quinquefasciatus. Compounds 1 and 2 (3,6,8-tribromo-7-hydroxy-4-methyl-chromen-2'-oxo-2H-chromen-7-yl acetate) showed remarkable ovicidal activity. Significant reduction of 80-85% hatching of eggs of both mosquito species was observed at the highest dose of 100 ppm. The hatched larvae showed 100% mortality in the successive instars. Compounds 3 and 4 (3-bromo-7-hydroxy-4-methyl-chromen-2-one and 3-bromo-4-methyl-2'-oxo-2H-chromen-7-yl acetate) showed moderate activity against both mosquito species.en_US
dc.description.affiliationDepartment of Chemistry, Sir Parshurambhau College, Pune 411 030, India. madhaviarya@rediffmail.comen_US
dc.identifier.citationDeshmukh M, Pawar P, Joseph M, Phalgune U, Kashalkar R, Deshpande NR. Efficacy of 4-methyl-7-hydroxy coumarin derivatives against vectors Aedes aegypti and Culex quinquefasciatus. Indian Journal of Experimental Biology. 2008 Nov; 46(11): 788-92en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/59728
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/4650/1/IJEB%2046%2811%29%20788-792.pdfen_US
dc.subject.meshAedes --drug effectsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiological Assayen_US
dc.subject.meshChemistry, Pharmaceutical --methodsen_US
dc.subject.meshCulex --drug effectsen_US
dc.subject.meshDrug Designen_US
dc.subject.meshDrug Evaluation, Preclinicalen_US
dc.subject.meshHymecromone --administration & dosageen_US
dc.subject.meshInsecticide Resistance --drug effectsen_US
dc.subject.meshInsecticides --pharmacologyen_US
dc.subject.meshLarva --drug effectsen_US
dc.subject.meshMagnetic Resonance Spectroscopyen_US
dc.subject.meshModels, Chemicalen_US
dc.subject.meshMosquito Controlen_US
dc.subject.meshPesticides --chemistryen_US
dc.titleEfficacy of 4-methyl-7-hydroxy coumarin derivatives against vectors Aedes aegypti and Culex quinquefasciatus.en_US
dc.typeJournal Articleen_US
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