Ethanolic Zingiber officinale R. extract pretreatment alleviates isoproterenol-induced oxidative myocardial necrosis in rats.

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dc.contributor.authorAnsari, M Nazamen_US
dc.contributor.authorBhandari, Uen_US
dc.contributor.authorPillai, K Ken_US
dc.date.accessioned2009-05-28T11:36:40Z
dc.date.available2009-05-28T11:36:40Z
dc.date.issued2006-11-09en_US
dc.description.abstractEthanolic Z. officinale (ZO) extract (200 mg/kg) pretreatment for 20 days in isoproterenol (ISO)-treated rats significantly increased the levels of endogenous myocardial antioxidants (catalase, superoxide dismutase and tissue glutathione), decreased the levels of serum marker enzymes (lactate dehydrogenase, creatine kinase, aspartate transaminase and alanine transaminase) and increased myocardial lipid peroxides. Histological examination of rat's heart section confirmed myocardial injury with ISO administration and near normal pattern with ethanolic ZO extract pretreatment. The results of the present study, for the first time, provide clear evidence that the ethanolic ZO extract pretreatment enhances the antioxidant defense against ISO-induced oxidative myocardial injury in rats and exhibit cardioprotective property.en_US
dc.description.affiliationDepartment of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110 062, India.en_US
dc.identifier.citationAnsari MN, Bhandari U, Pillai KK. Ethanolic Zingiber officinale R. extract pretreatment alleviates isoproterenol-induced oxidative myocardial necrosis in rats. Indian Journal of Experimental Biology. 2006 Nov; 44(11): 892-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/56955
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/6648/1/IJEB%2044%2811%29%20892-897.pdfen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntioxidants --analysisen_US
dc.subject.meshBiological Markers --blooden_US
dc.subject.meshEthanol --pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGinger --chemistryen_US
dc.subject.meshIsoproterenolen_US
dc.subject.meshLipid Peroxidation --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMyocardial Infarction --chemically induceden_US
dc.subject.meshMyocardium --pathologyen_US
dc.subject.meshNecrosis --drug therapyen_US
dc.subject.meshPlant Extracts --pharmacologyen_US
dc.subject.meshPlants, Medicinal --chemistryen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshSolvents --pharmacologyen_US
dc.titleEthanolic Zingiber officinale R. extract pretreatment alleviates isoproterenol-induced oxidative myocardial necrosis in rats.en_US
dc.typeComparative Studyen_US
dc.typeEvaluation Studiesen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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