Challenges, Approaches & Applications of Orotransmucosal Drug Delivery System

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dc.contributor.authorMahmud, Hen_US
dc.contributor.authorHimi, ASen_US
dc.contributor.authorRana, MSen_US
dc.contributor.authorKamrunnaharen_US
dc.contributor.authorRifat, MMHen_US
dc.contributor.authorIslam, S.en_US
dc.date.accessioned2025-05-12T10:23:18Z
dc.date.available2025-05-12T10:23:18Z
dc.date.issued2024-12
dc.description.abstractOrotransmucosal drug delivery is an alternative method used for a systemic drug delivery system. It is used as a favored route for non-parenteral administration of emergency drugs and agents. It can be used both for lipid-soluble and water-soluble drugs. It increases drug solubility and reduces in permeability of the lipid bilayer membrane. Mucosal surfaces are often rich in blood supply, allowing for rapid drug transport into the systemic circulation and in most cases avoiding degradation by first-pass hepatic metabolism. These systems contact with absorbent surfaces improves absorption at the application site and increases dwell time. It involves several physiological features of the oral cavity. Technical difficulties and biological impediments can be used as broad categories to group oral administration issues. Orotransmucosal drug delivery system uses an absorption rate four times that of the skin. It is easily accessible and heals rapidly from trauma and injury. It has a smaller surface area than the skin and can only be exposed for brief periods of time. Thus, this delivery method is the best for medications with high therapeutic potency. Efficient orotransmucosal drug delivery can be achieved in the oral cavity's buccal, sublingual, palatal and gingival regions. Mastication or chewing food can improve or impair medication absorption in the oral cavity. Mucoadhesive drug delivery systems can be lost or damaged when used to fill chewing gum with drugs that are released when the chewing gum is chewed. This report also provides input for future orotransmucosal drug developments to treat oral mucosa diseases.en_US
dc.identifier.affiliationsDepartment of Pharmacy, University of Asia Pacific, Dhaka, Bangladeshen_US
dc.identifier.affiliationsDepartment of Pharmacy, University of Asia Pacific, Dhaka, Bangladeshen_US
dc.identifier.affiliationsDepartment of Pharmacy, Jahangirnagar University, Dhaka, Bangladeshen_US
dc.identifier.affiliationsDepartment of Pharmacy, State University of Bangladesh, Dhaka, Bangladeshen_US
dc.identifier.affiliationsDepartment of Pharmacy, University of Asia Pacific, Dhaka, Bangladeshen_US
dc.identifier.affiliationsDepartment of Pharmacy, University of Asia Pacific, Dhaka, Bangladesh.en_US
dc.identifier.citationMahmud H, Himi AS, Rana MS, Kamrunnahar, Rifat MMH, Islam S.. Challenges, Approaches & Applications of Orotransmucosal Drug Delivery System . Journal of Pharmaceutical Research International. 2024 Dec; 36(12): 32-53en_US
dc.identifier.issn2456-9119
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/247689
dc.languageenen_US
dc.publisherMs. M. B. Mondalen_US
dc.relation.issuenumber12en_US
dc.relation.volume36en_US
dc.source.urihttps://doi.org/10.9734/jpri/2024/v36i127627en_US
dc.subjectOrotransmucosalen_US
dc.subjecttransmucosalen_US
dc.subjectmucosalen_US
dc.subjectoral mucosaen_US
dc.subjectmucosaeen_US
dc.subjectmucoadhesionen_US
dc.subjectmucoadhesiveen_US
dc.subjectOTFCen_US
dc.titleChallenges, Approaches & Applications of Orotransmucosal Drug Delivery Systemen_US
dc.typeJournal Articleen_US
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