A short communication on Oncocytic Lesions of the Thyroid gland
No Thumbnail Available
Date
2025-05
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Educational Society for Excellence
Abstract
Oncocytic lesions of the thyroid, often referred to as Hurthle cell lesions or oncocytic changes, represent a subset of thyroid pathologies characterized by mitochondrial-rich, eosinophilic cytoplasm. Oncocytic lesions of the thyroid are covering a wide spectrum of lesions e.g. benign hyperplastic nodules to malignant thyroid neoplasms. It is very important to understand their biology, diagnostic challenges, and management strategies for clinicians as well as pathologists alike. The most common clinical presentation of patients with oncocytic thyroid lesions is a painless thyroid nodule which is discovered incidentally or during evaluation for goiter or any other thyroid lesion. According to the WHO 2022 Classification of Tumors of Endocrine Organs, oncocytic lesions of the thyroid are recognized as a distinct subset of follicular-derived neoplasms. The WHO emphasizes the importance of rigorous histopathological criteria to differentiate benign from malignant oncocytic lesions and the need for molecular profiling to complement histological findings. Ongoing research will help to refine management approaches, principally for malignant oncocytic lesions. It is very much needed that endocrinologists, pathologists, and treating surgeons collaborate with each other for optimizing patient outcomes. This article emphasized on unique clinical, diagnostic, therapeutic and pathological aspects of oncocytic thyroid lesions
Description
Keywords
Oncocytic lesions, Thyroid neoplasm, WHO 2022 Classification, Histopathological criteria.
Citation
Rathod G, Banka SS, Mishra M, Parmar P. A short communication on Oncocytic Lesions of the Thyroid gland. International Archives of Integrated Medicine. 2025 May; 12(5): 9-12