Systemic Biomarkers in Predicting Clinical Outcomes among Patients with Non-ST Segment Elevation Myocardial Infarction: A Systematic Review

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dc.contributor.authorEchere, Jen_US
dc.contributor.authorSayegh, Gen_US
dc.contributor.authorAsaju, Fen_US
dc.contributor.authorOkafor, ENen_US
dc.contributor.authorOguntuase, OAen_US
dc.contributor.authorLeukeu, AJen_US
dc.contributor.authorAdetunji, EOAen_US
dc.contributor.authorBadr, Oen_US
dc.contributor.authorBrown, SMen_US
dc.contributor.authorSultana, Sen_US
dc.contributor.authorAzipu, Ren_US
dc.contributor.authorEzewudo, Oen_US
dc.contributor.authorObi, Men_US
dc.contributor.authorFerguson, Fen_US
dc.contributor.authorGopal, S.en_US
dc.date.accessioned2024-11-30T08:52:07Z
dc.date.available2024-11-30T08:52:07Z
dc.date.issued2024-08
dc.description.abstractBackground: The ability to predict clinical outcomes in Non-ST Segment Elevation Myocardial Infarction (NSTEMI) could potentially lead to better risk stratification and treatment management. This systematic review aims to evaluate the predictive value of systemic biomarkers on the clinical outcomes among NSTEMI patients. Methods: A comprehensive search across PubMed, Web of Science and Scopus was conducted, adhering to PRISMA Statement 2020 guidelines. Original clinical studies involving NSTEMI patients with measured systemic biomarkers were considered. Keyword combinations included the following: 'NSTEMI', 'systemic biomarkers', 'clinical outcomes', 'major adverse cardiac events', and/or 'mortality. Results: We included 7 studies in total pooling in 863 participants, with biomarkers such as Syntax score, Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), Matrix Metallopeptidase 9 (MMP-9), and Perforin (P), among others. All systemic inflammation (SI) biomarkers were found significantly elevated in patients with high Syntax scores. ROC values for major adverse cardiac events (MACE) ranged from 0.592 to 0.637, and for overall mortality from 0.524 to 0.761. Monocytic MMP-9 mRNA levels were found increased in patients with NSTEMI (0.9 +/- 0.3 relative units (RU)). Positive correlations were found between cardiac troponin I plasma concentrations and the frequency of Perforin-positive cells during the first week after the NSTEMI. Conclusion: Systemic biomarkers, including Syntax score, NLR, PLR, MMP-9, and Perforin, show potential predictive value for clinical outcomes in NSTEMI patients. Their use could aid in early risk stratification and management. However, more large-scale, multicenter studies are warranted to validate these findings.en_US
dc.identifier.affiliationsThe University of Texas Health Science Center at Houston School of Public Health, USAen_US
dc.identifier.affiliationsRoss University School of Medicine, USAen_US
dc.identifier.affiliationsDelta State University College of Health Sciences, Nigeriaen_US
dc.identifier.affiliationsSumy State University Medical Institute, Ukraineen_US
dc.identifier.affiliationsCaribbean Medical University, Curaçaoen_US
dc.identifier.affiliationsXavier University School of Medicine, Arubaen_US
dc.identifier.affiliationsKharkiv National Medical University, Ukraineen_US
dc.identifier.affiliationsAlexandria University Faculty of Medicine, Egypten_US
dc.identifier.affiliationsQueens University College of Medicine, Barbadosen_US
dc.identifier.affiliationsSiddhartha Medical College (SMC), Indiaen_US
dc.identifier.affiliationsUniversity of Calabar College of Medical Sciences, Nigeriaen_US
dc.identifier.affiliationsCollege of Medicine, University of Nigeria, Nigeriaen_US
dc.identifier.affiliationsMadonna University College of Medicine, Nigeriaen_US
dc.identifier.affiliationsSumma Health, USAen_US
dc.identifier.affiliationsBassett Medical Center, USA.en_US
dc.identifier.citationEchere J, Sayegh G, Asaju F, Okafor EN, Oguntuase OA, Leukeu AJ, Adetunji EOA, Badr O, Brown SM, Sultana S, Azipu R, Ezewudo O, Obi M, Ferguson F, Gopal S.. Systemic Biomarkers in Predicting Clinical Outcomes among Patients with Non-ST Segment Elevation Myocardial Infarction: A Systematic Review. Journal of Advances in Medicine and Medical Research. 2024 Aug; 36(9): 45-55en_US
dc.identifier.issn2456-8899
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/237248
dc.languageenen_US
dc.publisherMs. M. B. Mondalen_US
dc.relation.issuenumber9en_US
dc.relation.volume36en_US
dc.source.urihttps://doi.org/10.9734/jammr/2024/v36i95556en_US
dc.subjectSystemic biomarkersen_US
dc.subjectNon-ST segment elevation myocardial infarctionen_US
dc.subjectpredictive valueen_US
dc.subjectrisk stratificationen_US
dc.subjectsyntax scoreen_US
dc.subjectneutrophil-to-lymphocyte ratioen_US
dc.subjectplatelet-to-lymphocyte ratioen_US
dc.titleSystemic Biomarkers in Predicting Clinical Outcomes among Patients with Non-ST Segment Elevation Myocardial Infarction: A Systematic Reviewen_US
dc.typeJournal Articleen_US
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