A multicentric study with arteether in patients of uncomplicated falciparum malaria.

Asthana, O P; Srivastava, J S; Kamboj, V P; Valecha, N; Sharma, V P; Gupta, S; Pande, T K; Vishwanathan, K A; Mahapatra, K M; Nayak, N C; Mahapatra, P K; Mahanta, J; Srivastava, V K; Vasdev,; Singh, N; Shukla, M M; Balsara, A B; Mishra, S K; Satpathy, S K; Mohanty, S; Dash, B

A multicentric study with arteether in patients of uncomplicated falciparum malaria.

Date

2001-07-28

Authors

Abstract

Two hundred and sixty seven patients of uncomplicated P. falciparum malaria completed study in a multicentric phase III clinical trial of Arteether. Arteether was given intramuscularly in a dose of 150 mg daily for three consecutive days. Each patient was followed upto 28 days of alpha, beta arteether therapy. The cure rate was 97% with fever clearance time between 1-7 days (24-168 hours) and parasite clearance time between 1-3 days (24-72 hours). Parasite reappearance rate was found to be 3% and reported at only three of the centres. Following the treatment no adverse effect was observed on haematological, biochemical and vital clinical parameters.

Citation

Asthana OP, Srivastava JS, Kamboj VP, Valecha N, Sharma VP, Gupta S, Pande TK, Vishwanathan KA, Mahapatra KM, Nayak NC, Mahapatra PK, Mahanta J, Srivastava VK, Vasdev , Singh N, Shukla MM, Balsara AB, Mishra SK, Satpathy SK, Mohanty S, Dash B. A multicentric study with arteether in patients of uncomplicated falciparum malaria. Journal of the Association of Physicians of India. 2001 Jul; 49(): 692-6