Antileishmanial efficacy of Boerhaavia diffusa L. and Ocimum sanctum L. against experimental visceral leishmaniasis.

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dc.contributor.authorKaur, S
dc.contributor.authorBhardwaj, K
dc.contributor.authorSachdeva, H
dc.date.accessioned2016-11-18T07:24:44Z
dc.date.available2016-11-18T07:24:44Z
dc.date.issued2015-08
dc.description.abstractThe chemotherapy of visceral leishmaniasis (VL) has several limitations including resistance and toxicity of the existing drugs. Down regulation of immune system further aggravates the problems. To combat this situation we evaluated the leishmanicidal efficacy of Boerhaavia diffusa and Ocimum sanctum through oral route in L. donovani infection in BALB/c mice. Results have demonstrated maximum clearance of the parasites from infected animals treated with combination of B. diffusa and O. sanctum (@ 100 and 400 mg/kg body wt., respectively 5 days) as depicted through Leishman Donovan Units in liver. Up-regulation of cell-mediated immunity was also observed in animals of this group as heightened delayed type hypersensitivity responses and increased IgG2a levels were observed. Moreover, increased levels of SGOT, SGPT, serum urea, blood urea nitrogen and serum creatinine were brought down to normal levels. Since VL is associated immunosuppression, the above treatment is a good option as it helps in the up-regulation of Th1 responses and reduction in parasite load in L. donovani infected mice. These findings suggest a new option for antileishmanial chemotherapy at lower cost and nil toxicity.en_US
dc.identifier.citationKaur S, Bhardwaj K, Sachdeva H. Antileishmanial efficacy of Boerhaavia diffusa L. and Ocimum sanctum L. against experimental visceral leishmaniasis. Indian Journal of Experimental Biology. 2015 Aug; 53(8): 522-529.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/178547
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/31911en_US
dc.subjectBlack feveren_US
dc.subjectDumdum feveren_US
dc.subjectFolk medicineen_US
dc.subjectHerbalen_US
dc.subjectHoly basilen_US
dc.subjectIndian medicineen_US
dc.subjectKala-azar Punarnavaen_US
dc.subjectRed spiderlingen_US
dc.subjectSanthien_US
dc.subjectTarvineen_US
dc.subjectThulasien_US
dc.titleAntileishmanial efficacy of Boerhaavia diffusa L. and Ocimum sanctum L. against experimental visceral leishmaniasis.en_US
dc.typeArticleen_US
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