Exploitation of fermented shrimp-shells hydrolysate as functional food: Assessment of antioxidant, hypocholesterolemic and prebiotic activities.

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dc.contributor.authorHalder, Suman Kumar
dc.contributor.authorAdak, Atanu
dc.contributor.authorMaity, Chiranjit
dc.contributor.authorJana, Arijit
dc.contributor.authorDas, Arpan
dc.contributor.authorPaul, Tanmay
dc.contributor.authorGhosh, Kuntal
dc.contributor.authorMohapatra, Pradeep Kumar Das
dc.contributor.authorPati, Bikas Ranjan
dc.contributor.authorMondal, Keshab Chandra
dc.date.accessioned2013-11-19T09:01:01Z
dc.date.available2013-11-19T09:01:01Z
dc.date.issued2013-11
dc.description.abstractIn the present study the bioactivities of chitooligosaccharides of fermented shrimp-shell hydrolysate (SSH) in respect to hypocholesterolemic, antioxidant and prebiotic activity were tested in male albino rat. Rats were treated with four different diets, viz., (i) cholesterol-rich (5%) basal diet (ChB), (ii) ChB+10% chitin, (iii) ChB+10% SSH and (iv) control group (without cholesterol). After 4 weeks of treatment, body mass index, liver weight, serum total cholesterol and LDL-cholesterol in groups (ii) and (iii) were decreased significantly than group (i). SSH supplementation significantly resists oxidative stress by reducing the thiobarbituric acid reactive substances and by increasing catalase, superoxide dismutase and free radical scavenging activity. The colonization of Lactobacillus and Bifidobacterium population in small and large intestine were more in group (iii) than other groups. Reduction of Clostridium perfringens population and non-significant changes of E. coli was also noted in SSH supplement group. Histological study revealed that the villus height and villus:crypt of the small intestine were increased significantly in SSH supplemented group (iii) without any diarrheal symptoms. The results demonstrated that the shrimp-shells hydrolysate has hypocholesterolemic effect, can resist lipid peroxidation and can influence the growth of health beneficial microbes, hence can be used as functional food for hypercholesterolemic patients.en_US
dc.identifier.citationHalder Suman Kumar, Adak Atanu, Maity Chiranjit, Jana Arijit, Das Arpan, Paul Tanmay, Ghosh Kuntal, Mohapatra Pradeep Kumar Das, Pati Bikas Ranjan, Mondal Keshab Chandra. Exploitation of fermented shrimp-shells hydrolysate as functional food: Assessment of antioxidant, hypocholesterolemic and prebiotic activities. Indian Journal of Experimental Biology. 2013 Nov; 51(11): 924-934.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/149399
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/23455en_US
dc.subjectAeromonas hydrophilaen_US
dc.subjectAntioxidanten_US
dc.subjectFunctional fooden_US
dc.subjectHypocholesterolemicen_US
dc.subjectOxidative stressen_US
dc.subjectShrimp-shells hydrolysateen_US
dc.titleExploitation of fermented shrimp-shells hydrolysate as functional food: Assessment of antioxidant, hypocholesterolemic and prebiotic activities.en_US
dc.typeArticleen_US
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