Detection of autoreactive antibodies to serum IgG and IgA in amoebic liver abscess cases.

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dc.contributor.authorNayeem, M Aen_US
dc.contributor.authorIshaq, Men_US
dc.contributor.authorHabibullah, C Men_US
dc.contributor.authorBegum, Sen_US
dc.date.accessioned2009-05-28T14:57:12Z
dc.date.available2009-05-28T14:57:12Z
dc.date.issued1992-06-01en_US
dc.description.abstractAssessment of autoreactive antibodies in response to healthy human serum IgA and IgG was performed by indirect haemagglutination assay on serum samples from 81 amoebic liver abscess cases for IgA and 70 for IgG. Appropriate controls were taken simultaneously. IgA, IgG were isolated and purified from a healthy human serum through Sephadex G-200 and protein A CL 4B sepharose chromatography. These immunoglobulins were used for the detection of its own antibodies in amoebic liver abscess cases. This revealed that 43.20% and 48.50% of the cases were positive for IgA and IgG respectively, where as only 19.35% and 28.30% of the controls were in positive category (IgA and IgG respectively). The mean titres with standard deviation of the autoreactive antibodies to serum IgA both in ALA cases and controls shows a highly significant difference between tests and controls (P less than 0.001). Similarly the mean titres with standard deviation both in ALA and controls for the serum IgG differed significantly (P less than 0.001). This suggests the presence of autoreactive antibodies against serum IgA and IgG in amoebic liver abscess cases.en_US
dc.description.affiliationDepartment of Gastroenterology, Osmania General Hospital, Osmania Medical College, Hyderabad, India.en_US
dc.identifier.citationNayeem MA, Ishaq M, Habibullah CM, Begum S. Detection of autoreactive antibodies to serum IgG and IgA in amoebic liver abscess cases. Indian Journal of Experimental Biology. 1992 Jun; 30(6): 549-51en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/61368
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAntibodies, Anti-Idiotypic --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin A --immunologyen_US
dc.subject.meshImmunoglobulin G --immunologyen_US
dc.subject.meshLiver Abscess, Amebic --immunologyen_US
dc.titleDetection of autoreactive antibodies to serum IgG and IgA in amoebic liver abscess cases.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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