Studies On Bioavailability Enhancement Of Curcumin

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dc.contributor.authorKotagale, N. R.en_US
dc.contributor.authorCharde, P. B.en_US
dc.contributor.authorHelonde, A.en_US
dc.contributor.authorGupta, K. R.en_US
dc.contributor.authorUmekar, M. J.en_US
dc.contributor.authorRaut, N. S.en_US
dc.date.accessioned2020-09-24T08:01:44Z
dc.date.available2020-09-24T08:01:44Z
dc.date.issued2020-02
dc.description.abstractObjective: The objective of the present work was to improve aqueous solubility and in vivo bioavailability of curcumin and structural analogues of curcumin such as potassium, calcium, magnesium salts and nitro derivative. Methods: Structural analogues of curcumin were prepared by reaction of curcumin with potassium chloride, magnesium chloride hexahydrate and calcium chloride dihydrate in a suitable solvent. The nitro derivative synthesized by treating curcumin with sulphuric acid and nitric acid. The prepared analogues were evaluated for melting behavior, solubility, UV spectrophotometry, partition coefficient, moisture content, cellular uptake, FTIR analysis, antimicrobial activity and in vivo bioavailability in the rat. Results: Chemical modification of curcumin increased the saturation solubility to 11.6, 16.5, 21.5, 28.0 µg/ml in calcium salt, magnesium salt, potassium salt and nitro derivative respectively, against 8.6 µg/ml of curcumin. The analogues were chemically stable as curcumin analyzed by FTIR spectrophotometry. Increased cellular uptake, as well as enhanced antimicrobial activity, was demonstrated by modified curcumin analogues. Moreover, significant improvement in plasma levels was estimated with nitro derivative. Conclusion: The present work recommends that nitration of curcumin improves aqueous solubility which may improve absorption and in vivo bioavailability.en_US
dc.identifier.affiliationsDepartment of Pharmaceutical Chemistry, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, India 441002en_US
dc.identifier.affiliationsDepartment of Pharmaceutical Chemistry, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, India 441002en_US
dc.identifier.affiliationsDepartment of Pharmaceutical Chemistry, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, India 441002en_US
dc.identifier.affiliationsDepartment of Pharmaceutical Chemistry, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, India 441002en_US
dc.identifier.affiliationsDepartment of Pharmaceutical Chemistry, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, India 441002en_US
dc.identifier.affiliationsDepartment of Pharmaceutical Chemistry, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, India 441002en_US
dc.identifier.citationKotagale N. R., Charde P. B., Helonde A., Gupta K. R., Umekar M. J., Raut N. S.. Studies On Bioavailability Enhancement Of Curcumin. International Journal of Pharmacy and Pharmaceutical Sciences. 2020 Feb; 12(2): 20-25en_US
dc.identifier.issn0975-1491
dc.identifier.issn2656-0097
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/206037
dc.languageenen_US
dc.publisherInnovare Academic Sciences Pvt. Ltd.en_US
dc.relation.issuenumber2en_US
dc.relation.volume12en_US
dc.source.urihttps://doi.org/10.22159/ijpps.2020v12i2.36027en_US
dc.subjectCurcuminen_US
dc.subjectStructural analoguesen_US
dc.subjectBioavailabilityen_US
dc.subjectAntimicrobial activityen_US
dc.titleStudies On Bioavailability Enhancement Of Curcuminen_US
dc.typeJournal Articleen_US
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