PREBIOTIC EFFICACY OF DEFATTED FENUGREEK SEED FLAKES (FENUFLAKESTM): A SHORT-TERM COLONIC SIMULATION STUDY

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dc.contributor.authorTHAKURDESAI, Pen_US
dc.contributor.authorDESHPANDE, Pen_US
dc.contributor.authorNIMSE, Sen_US
dc.contributor.authorBHASKARAN, Sen_US
dc.contributor.authorKARVE, Men_US
dc.contributor.authorRAJE, D.en_US
dc.date.accessioned2025-05-12T07:20:48Z
dc.date.available2025-05-12T07:20:48Z
dc.date.issued2024-11
dc.description.abstractObjective: To investigate the prebiotic effects of defatted fenugreek seed flakes (Fenuflakes™) using a 48-hour colonic simulation model. Methods: Fecal samples from three healthy adult human donors were exposed to treatment conditions of blank (medium control), Fenuflakes, or inulin (fiber control). The effects on microbial fermentation (pH and gas production), metabolite production [Short Chain Fatty Acid (SCFAs), Branched-Chain Fatty Acid (BCFA), ammonium and lactate production], and microbial community composition were evaluated at 0, 6, 24, and 48 h. Results: In comparison to inulin, Fenuflakes demonstrated a significant reduction in gas production. Both inulin and Fenuflakes significantly increased beneficial SCFAs, but no significant change was observed in BCFA. Ammonium production increased upon Fenuflakes treatment due to a residual protein fraction reaching the colon, in contrast to inulin, which is in a protein-depleted state. The lactate levels significantly increased for Fenuflakes and inulin. The presence of Fenuflakes and inulin resulted in favorable fermentation by the colonic gut microbiota, indicating an increase in species enrichment and alpha diversity in the microbial community composition. Conclusion: Fenuflakes exhibit prebiotic potential by increasing SCFA and promoting the enrichment of several beneficial colonic bacteria while maintaining normal colonic pH and producing less gas than inulin.en_US
dc.identifier.affiliationsIndus Biotech Limited, 1, Rahul residency, off Salunke Vihar Road, Kondhwa, Pune-411026, Indiaen_US
dc.identifier.affiliationsIndus Biotech Limited, 1, Rahul residency, off Salunke Vihar Road, Kondhwa, Pune-411026, Indiaen_US
dc.identifier.affiliationsIndus Biotech Limited, 1, Rahul residency, off Salunke Vihar Road, Kondhwa, Pune-411026, Indiaen_US
dc.identifier.affiliationsIndus Biotech Limited, 1, Rahul residency, off Salunke Vihar Road, Kondhwa, Pune-411026, Indiaen_US
dc.identifier.affiliationsIndus Biotech Limited, 1, Rahul residency, off Salunke Vihar Road, Kondhwa, Pune-411026, Indiaen_US
dc.identifier.affiliationsAlfa Level Consultants, 96, East Samarth Nagar, Wardha Road, Nagpur-440015, Indiaen_US
dc.identifier.citationTHAKURDESAI P, DESHPANDE P, NIMSE S, BHASKARAN S, KARVE M, RAJE D.. PREBIOTIC EFFICACY OF DEFATTED FENUGREEK SEED FLAKES (FENUFLAKESTM): A SHORT-TERM COLONIC SIMULATION STUDY . International Journal of Pharmacy and Pharmaceutical Sciences . 2024 Nov; 16(11): 50-59en_US
dc.identifier.issn0975-1491
dc.identifier.issn2656-0097
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/246447
dc.languageenen_US
dc.publisherInnovare Academic Sciences Pvt. Ltd.en_US
dc.relation.issuenumber11en_US
dc.relation.volume16en_US
dc.source.urihttps://doi.org/10.22159/ijpps.2024v16i11.52414en_US
dc.subjectPrebioticen_US
dc.subjectShort-chain fatty acidsen_US
dc.subjectfenugreek flakesen_US
dc.subjectColonic simulationen_US
dc.titlePREBIOTIC EFFICACY OF DEFATTED FENUGREEK SEED FLAKES (FENUFLAKESTM): A SHORT-TERM COLONIC SIMULATION STUDYen_US
dc.typeJournal Articleen_US
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