A Review of Antifungal Activity of Combined Plant Extracts or Plant Exudates from Medicinal Plants either together or with Known Antifungal Agents

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dc.contributor.authorHaji, M. H.en_US
dc.contributor.authorMohamed, A. B.en_US
dc.contributor.authorAlbashir, A. A.en_US
dc.contributor.authorMirghani, M.en_US
dc.date.accessioned2023-07-14T08:07:03Z
dc.date.available2023-07-14T08:07:03Z
dc.date.issued2022-08
dc.description.abstractMedicinal plants provide humanity with important phytochemical compounds and extracts which are widely used in treatment of many diseases. Fungal infections are one of these diseases which are widely distributed especially in developing countries; medicinal plants are extensively used in developing countries. There are few antifungal agents, most of them are expensive and have many adverse effects, also there is high incidence of drug resistance among some available antifungal agents, hence for these mentioned reasons many people, especially in developing countries, use medicinal plants (either alone, combined together or combined with known antifungal drugs) in treatment of many fungal infections. This rise a new and important issue about plant(s) – plant(s) and plant(s) - drug interactions. The aim of this review is to try to fill the gap in understanding the interactions of plant(s) - plant(s) and plant(s) – drug(s) combinations by providing an overview of some evidence-based researches done in this field, so our review highlights many interactions between medicinal plants constituents with current available antifungal agents, these interactions may be synergistic, additive, indifferent or antagonistic, so, if there is any antagonistic effect, we recommend to avoid using the combination which caused this effect. We collected a lot of studies which studied the interactions between plant(s) (including extracts, isolated active constituents, essential oils, plants latexes and other phytochemicals) used either together or with conventional antifungal agents. This will not only bring about better understanding of both phytochemicals and antifungal activity, but also may help in searching and developing new safely and effective drugs, specially with those combinations which showed synergistic effect.en_US
dc.identifier.affiliationsDepartment of Pharmacognosy, Faculty of Pharmacy, International University of Africa, Khartoum, Sudanen_US
dc.identifier.citationHaji M. H., Mohamed A. B., Albashir A. A., Mirghani M.. A Review of Antifungal Activity of Combined Plant Extracts or Plant Exudates from Medicinal Plants either together or with Known Antifungal Agents. European Journal of Medicinal Plants. 2022 Aug; 33(8): 16-47en_US
dc.identifier.issn2231-0894
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/219500
dc.languageenen_US
dc.publisherSciencedomain Internationalen_US
dc.relation.issuenumber8en_US
dc.relation.volume33en_US
dc.source.urihttps://doi.org/10.9734/ejmp/2022/v33i830483en_US
dc.subjectAntifungal activityen_US
dc.subjectplant-plant combinationen_US
dc.subjectplant-drug combinationen_US
dc.subjectsynergismen_US
dc.titleA Review of Antifungal Activity of Combined Plant Extracts or Plant Exudates from Medicinal Plants either together or with Known Antifungal Agentsen_US
dc.typeJournal Articleen_US
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