Antioxidant activities of dithiol alpha-lipoic acid.
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Date
2009-06
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Abstract
Alpha-lipoic acid, a dithiol compound derived from octanoic acid, which acts as a coenzyme for
several redox reactions in almost all the tissue of the body. It retains its protective functions in
both oxidized and reduced forms. Alpha-lipoic acid reduces oxidative stress by redox generation
of other antioxidants such as vitamin C, E and increasing the intracellular glutathione. Exogenous
alpha-lipoic acid has been shown to increase ATP production due to its role in the oxidation of
pyruvate and alpha-ketoglutarate in the mitochondria. Alpha-lipoic acid administration has been
shown to be effective in preventing pathology in various experimental models in which reactive
oxygen species have been implicated.
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Keywords
Antioxidant, free radical, alpha-lipoic acid
Citation
Islam M T. Antioxidant activities of dithiol alpha-lipoic acid. Bangladesh Journal of Medical Science. 2009; 8(3): 46-51.