Antisickling and Radical Scavenging Activities of Selected Medicinal Plants and Compounds from Mitracarpus villosus (Sw.) DC. Cham

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dc.contributor.authorElusiyan, Christianah A.en_US
dc.contributor.authorAyoade, Opeyemien_US
dc.contributor.authorAdeloye, Adewale O.en_US
dc.contributor.authorOlorunmola, Felix O.en_US
dc.contributor.authorAgbedahunsi, Joseph M.en_US
dc.contributor.authorOgundaini, Abiodun O.en_US
dc.date.accessioned2020-01-02T06:14:02Z
dc.date.available2020-01-02T06:14:02Z
dc.date.issued2018-07
dc.description.abstractAims: This study investigated the antisickling and radical scavenging activities of different morphological parts of nine plants, belonging to six families. A bioassay-guided fractionation was carried out on Mitracarpus villosus (Sw.) DC. Cham, which was one of the most active plants. Place and Duration of Study: Drug Research and Production Unit, Faculty of Pharmacy, Obafemi Awolowo University (OAU), Ile Ife, Nigeria between May 2013 and June 2016. Methodology: Plant materials were collected from OAU campus and Ile-Ife town, identified and voucher specimen deposited at IFE herbarium, OAU for future reference. In-vitro radical scavenging and antisickling (by haemoglobin polymerization inhibitory test) activities of extracts and isolated compounds were performed using ascorbic acid and vanillic acid as positive controls respectively. Bioassay-guided fractionation was achieved by combination of various chromatographic procedures and bioassay techniques to isolate the active constituents. Structural elucidation of the isolated compounds was by spectroscopic techniques including NMR and MS. Results: Six of the nine plant extracts showed considerable antisickling and antioxidant activities. Extracts of Emilia praetermissa and M. villosus, were however the most active. Extracts or compound which demonstrated strong radical scavenging activity were also found to demonstrate significant antisickling effects. Bioassay-guided fractionation of M. villosus resulted in the isolation of psychorubrin, quercetin and a mixture consisting of stigmasterol and an unidentified terpene. Quercetin was the most active antisickling and radical scavenging compound with percentage inhibition of 96.46±0.3 and 87.99±0.18 respectively. Conclusion: Mitracarpus villosus ranked second best in activity among the tested plants. Antisickling activity of its isolated compounds was found to increase with increase in the antioxidant capability of the compounds. Quercetin was the most active compound while the non-antioxidant terpenoidal mixture had very weak polymerisation inhibitory effect.en_US
dc.identifier.affiliationsDrug Research and Production Unit, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, 220005 Osun State, Nigeriaen_US
dc.identifier.affiliationsDrug Research and Production Unit, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, 220005 Osun State, Nigeriaen_US
dc.identifier.affiliationsNatural Resources and Materials, Botswana Institute for Technology Research and Innovation, Private Bag 0082, Gaborone, Republic of Botswanaen_US
dc.identifier.affiliationsDrug Research and Production Unit, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, 220005 Osun State, Nigeriaen_US
dc.identifier.affiliationsDrug Research and Production Unit, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, 220005 Osun State, Nigeriaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, 220005 Osun State, Nigeriaen_US
dc.identifier.citationElusiyan Christianah A., Ayoade Opeyemi, Adeloye Adewale O., Olorunmola Felix O., Agbedahunsi Joseph M., Ogundaini Abiodun O.. Antisickling and Radical Scavenging Activities of Selected Medicinal Plants and Compounds from Mitracarpus villosus (Sw.) DC. Cham. European Journal of Medicinal Plants. 2018 Jul; 24(4): 1-10en_US
dc.identifier.issn2231-0894
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/189405
dc.languageenen_US
dc.publisherScience Domain Internationalen_US
dc.relation.issuenumber4en_US
dc.relation.volume24en_US
dc.source.urihttps://doi.org/10.9734/EJMP/2018/42706en_US
dc.subjectAntisicklingen_US
dc.subjectantioxidanten_US
dc.subjectM villosusen_US
dc.subjectpsychorubrinen_US
dc.subjectquercetinen_US
dc.titleAntisickling and Radical Scavenging Activities of Selected Medicinal Plants and Compounds from Mitracarpus villosus (Sw.) DC. Chamen_US
dc.typeJournal Articleen_US
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