Vulvar Paget’s Disease with Inguinal Lymph Node Metastasis: A Case Report
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Date
2024-09
Journal Title
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Volume Title
Publisher
Ms. M. B. Mondal
Abstract
Vulvar Paget's disease is a clinical condition with an invariable course affecting women of advanced age, and is associated with a significant rate of recurrence and dissemination, especially in its invasive form, which has a high metastatic potential. Here we present details of a unique case involving a 77-year-old woman with a history of disease progression over more than a decade. She initially presented with an erythematous lesion in the vulvar region, which was later diagnosed as adenocarcinoma in situ. During follow-up, the affected area extended to the perineal and gluteal regions, indicating an invasive aspect of the tumor. Due to surgical oncology recommendations, tissue resection was not feasible. The pacient experienced a significant worsening of symptoms, including local peeling of the affected region, and a biopsy confirmed Paget's disease in the vulvar region. Subsequently, imaging tests indicated changes in the volume of the inguinal lymph nodes. The patient underwent lymphadenectomy for histological analysis and to prevent systemic dissemination. Indicators of lymph node metastasis, suggestive of a gynecological primary site, were observed. Our case provides valuable insights for pathologists to consider the differential diagnosis of vulvar lesions.
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Keywords
Women’s health, gynecologic cancers, vulvar Paget’s disease, lymph node metastasis, case report
Citation
Santos HM dos, Amaral C dos S do, Neto OVZ, Silva DT de R e.. Vulvar Paget’s Disease with Inguinal Lymph Node Metastasis: A Case Report. Annual Research & Review in Biology. 2024 Sep; 39(10): 11-16