Immunological studies in oral submucous fibrosis.

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dc.contributor.authorShah, Nen_US
dc.contributor.authorKumar, Ren_US
dc.contributor.authorShah, M Ken_US
dc.date.accessioned2009-05-28T07:53:12Z
dc.date.available2009-05-28T07:53:12Z
dc.date.issued1994-07-01en_US
dc.description.abstractOral submucous fibrosis (OSMF) is a high risk precancerous condition. The possible role of immunological factors in the pathogenesis of this condition was evaluated in 113 cases and 25 controls. The male/female ratio was 1.5/1. The mean age of males was significantly lower than that of females. The mean ESR levels were within normal limits, but for a higher than 20 mm fall per hr. in 40% of the cases. The serum IgA, IgG, and IgM levels were elevated significantly as compared to the controls. Circulating auto-antibodies and tissue-deposited antibodies were also found in 33% and 40% of the cases, respectively. From the analysis of the results, it is difficult to ascribe an auto-immune basis for the causation of OSMF. The female bias and elder age group, the factors generally considered in favour of an immune disorder, was not found in our study. However, raised ESR in 40% and serum globulin levels in 47% of the patients, distinctly higher levels of serum immunoglobulins, and positivity for circulating and tissue deposited antibodies in 33% and 34% of the cases respectively, do indicate an immunological basis. Therefore, further studies are required to ascertain the role of cellular immune mechanism and genetic parameters to explain the etiopathogenesis of this complex clinical entity.en_US
dc.description.affiliationDepartment of Dental Surgery, All India Institute of Medical Sciences, New Delhi.en_US
dc.identifier.citationShah N, Kumar R, Shah MK. Immunological studies in oral submucous fibrosis. Indian Journal of Dental Research. 1994 Jul-Sep; 5(3): 81-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/51819
dc.language.isoengen_US
dc.source.urihttps://www.ijdr.inen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAutoantibodies --analysisen_US
dc.subject.meshAutoimmune Diseases --immunologyen_US
dc.subject.meshBlood Sedimentationen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunity, Mucosalen_US
dc.subject.meshImmunoglobulins --analysisen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMouth Mucosa --immunologyen_US
dc.subject.meshMouth Neoplasms --immunologyen_US
dc.subject.meshOral Submucous Fibrosis --immunologyen_US
dc.subject.meshPrecancerous Conditions --immunologyen_US
dc.titleImmunological studies in oral submucous fibrosis.en_US
dc.typeJournal Articleen_US
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