Studies on digoxin--14C-acetate incorporation in to digoxin and degenerative changes in the brain in rats administered digoxin.

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dc.contributor.authorRavikumar, Aen_US
dc.contributor.authorAugustine, Jen_US
dc.contributor.authorKurup, P Aen_US
dc.date.accessioned2009-05-28T13:18:45Z
dc.date.available2009-05-28T13:18:45Z
dc.date.issued2001-06-04en_US
dc.description.abstractThe human hypothalamus produces an endogenous membrane Na+-K+ ATPase inhibitor digoxin. Digoxin is a steroidal glycoside and could be synthesised by the isoprenoid pathway. The other metabolites of the isoprenoid pathway are cholesterol, dolichol and ubiquinone. We have tried to find out the extent of incorporation of 14C acetate into digoxin in rat brain. The effects of digoxin administration on the rat brain was also studied. The results show that the percentage incorporation of 14C acetate into digoxin is low but detectable. The maximum incorporation was observed for cholesterol, followed by dolichol and finally ubiquinone. The histopathological changes observed after digoxin administration were focal degeneration of the ganglion cells in the cerebrum and cerebellum. The carbohydrate components of the glycoproteins were reduced and the concentration of serotonin, dopamine, and epinephrine showed a significant increase. The role of digoxin in mediating neuronal cell death is discussed.en_US
dc.description.affiliationDepartment of Ncurology, Medical College Hospital, Trivandrum 695011, India.en_US
dc.identifier.citationRavikumar A, Augustine J, Kurup PA. Studies on digoxin--14C-acetate incorporation in to digoxin and degenerative changes in the brain in rats administered digoxin. Indian Journal of Experimental Biology. 2001 Jun; 39(6): 537-41en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/59243
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAcetates --metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBrain --metabolismen_US
dc.subject.meshCarbon Radioisotopes --metabolismen_US
dc.subject.meshDigoxin --administration & dosageen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.titleStudies on digoxin--14C-acetate incorporation in to digoxin and degenerative changes in the brain in rats administered digoxin.en_US
dc.typeJournal Articleen_US
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