Platelet-derived growth factor mediates interleukin-13-induced collagen I production in mouse airway fibroblasts.

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dc.contributor.authorLu, Jiamei
dc.contributor.authorZhu, Yanting
dc.contributor.authorFeng, Wei
dc.contributor.authorPan, Yilin
dc.contributor.authorLi, Shaojun
dc.contributor.authorHan, Dong
dc.contributor.authorLiu, Lu
dc.contributor.authorXie, Xinming
dc.contributor.authorWang, Guizuo
dc.contributor.authorManxiang, Li
dc.date.accessioned2015-08-18T04:02:52Z
dc.date.available2015-08-18T04:02:52Z
dc.date.issued2014-09
dc.description.abstractInterleukin-13 (IL-13) is associated with the production of collagen in airway remodelling of asthma. Yet, the molecular mechanisms underlying IL-13 induction of collagen remain unclear; the aim of this study is to address this issue. IL-13 dose- and time-dependently-induced collagen I production in primary cultured airway fibroblasts; this was accompanied with the STAT6 phosphorylation, and pre-treatment of cells with JAK inhibitor suppressed IL-13- induced collagen I production. Further study indicated that IL-13 stimulated JAK/STAT6-dependent PDGF production and subsequent ERK1/2 MAPK activation in airway fibroblasts, and the presence of either PDGF receptor blocker or MEK inhibitor partially suppressed IL-13-induced collagen I production. Taken together, our study suggests that activation of JAK/STAT6 signal pathway and subsequent PDGF generation and resultant ERK1/2 MAPK activation mediated IL-13-induced collagen I production in airway fibroblasts.en_US
dc.identifier.citationLu Jiamei, Zhu Yanting, Feng Wei, Pan Yilin, Li Shaojun, Han Dong, Liu Lu, Xie Xinming, Wang Guizuo, Li Manxiang. Platelet-derived growth factor mediates interleukin-13-induced collagen I production in mouse airway fibroblasts. Journal of Biosciences. 2014 Sep; 39 (4): 693-700.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/161982
dc.language.isoenen_US
dc.source.urihttps://www.ias.ac.in/jbiosci/sep2014/693.pdfen_US
dc.subjectAirway fibroblastsen_US
dc.subjectcollagen Ien_US
dc.subjectinterleukin-13en_US
dc.subjectPDGFen_US
dc.titlePlatelet-derived growth factor mediates interleukin-13-induced collagen I production in mouse airway fibroblasts.en_US
dc.typeArticleen_US
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