Platelet-derived growth factor mediates interleukin-13-induced collagen I production in mouse airway fibroblasts.
dc.contributor.author | Lu, Jiamei | |
dc.contributor.author | Zhu, Yanting | |
dc.contributor.author | Feng, Wei | |
dc.contributor.author | Pan, Yilin | |
dc.contributor.author | Li, Shaojun | |
dc.contributor.author | Han, Dong | |
dc.contributor.author | Liu, Lu | |
dc.contributor.author | Xie, Xinming | |
dc.contributor.author | Wang, Guizuo | |
dc.contributor.author | Manxiang, Li | |
dc.date.accessioned | 2015-08-18T04:02:52Z | |
dc.date.available | 2015-08-18T04:02:52Z | |
dc.date.issued | 2014-09 | |
dc.description.abstract | Interleukin-13 (IL-13) is associated with the production of collagen in airway remodelling of asthma. Yet, the molecular mechanisms underlying IL-13 induction of collagen remain unclear; the aim of this study is to address this issue. IL-13 dose- and time-dependently-induced collagen I production in primary cultured airway fibroblasts; this was accompanied with the STAT6 phosphorylation, and pre-treatment of cells with JAK inhibitor suppressed IL-13- induced collagen I production. Further study indicated that IL-13 stimulated JAK/STAT6-dependent PDGF production and subsequent ERK1/2 MAPK activation in airway fibroblasts, and the presence of either PDGF receptor blocker or MEK inhibitor partially suppressed IL-13-induced collagen I production. Taken together, our study suggests that activation of JAK/STAT6 signal pathway and subsequent PDGF generation and resultant ERK1/2 MAPK activation mediated IL-13-induced collagen I production in airway fibroblasts. | en_US |
dc.identifier.citation | Lu Jiamei, Zhu Yanting, Feng Wei, Pan Yilin, Li Shaojun, Han Dong, Liu Lu, Xie Xinming, Wang Guizuo, Li Manxiang. Platelet-derived growth factor mediates interleukin-13-induced collagen I production in mouse airway fibroblasts. Journal of Biosciences. 2014 Sep; 39 (4): 693-700. | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/161982 | |
dc.language.iso | en | en_US |
dc.source.uri | https://www.ias.ac.in/jbiosci/sep2014/693.pdf | en_US |
dc.subject | Airway fibroblasts | en_US |
dc.subject | collagen I | en_US |
dc.subject | interleukin-13 | en_US |
dc.subject | PDGF | en_US |
dc.title | Platelet-derived growth factor mediates interleukin-13-induced collagen I production in mouse airway fibroblasts. | en_US |
dc.type | Article | en_US |