Platelet-derived growth factor mediates interleukin-13-induced collagen I production in mouse airway fibroblasts.
Loading...
Date
2014-09
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Interleukin-13 (IL-13) is associated with the production of collagen in airway remodelling of asthma. Yet, the
molecular mechanisms underlying IL-13 induction of collagen remain unclear; the aim of this study is to address
this issue. IL-13 dose- and time-dependently-induced collagen I production in primary cultured airway fibroblasts; this
was accompanied with the STAT6 phosphorylation, and pre-treatment of cells with JAK inhibitor suppressed IL-13-
induced collagen I production. Further study indicated that IL-13 stimulated JAK/STAT6-dependent PDGF production
and subsequent ERK1/2 MAPK activation in airway fibroblasts, and the presence of either PDGF receptor
blocker or MEK inhibitor partially suppressed IL-13-induced collagen I production. Taken together, our study
suggests that activation of JAK/STAT6 signal pathway and subsequent PDGF generation and resultant ERK1/2
MAPK activation mediated IL-13-induced collagen I production in airway fibroblasts.
Description
Keywords
Airway fibroblasts, collagen I, interleukin-13, PDGF
Citation
Lu Jiamei, Zhu Yanting, Feng Wei, Pan Yilin, Li Shaojun, Han Dong, Liu Lu, Xie Xinming, Wang Guizuo, Li Manxiang. Platelet-derived growth factor mediates interleukin-13-induced collagen I production in mouse airway fibroblasts. Journal of Biosciences. 2014 Sep; 39 (4): 693-700.