Role of MMP-1, MMP-8 and MMP-9 gene polymorphisms in preterm birth

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dc.contributor.authorPandey, Monikaen_US
dc.contributor.authorAwasthi, Shallyen_US
dc.date.accessioned2020-11-18T10:21:11Z
dc.date.available2020-11-18T10:21:11Z
dc.date.issued2020-01
dc.description.abstractNovel approaches to preterm births are underway building upon our prior discoveries and probing into unknown discovery pathways. The recent findings showed a high affinity of MMP-9 in serum and its polymorphisms for preterm birth. This study, which is a hospital-based case– control study, aims to investigate the association of MMP-1, MMP-8 and MMP-9 polymorphisms, and levels of MMP-9 in preterm birth. Increased level of MMP-9 was reported in cases as compared to control. The significant association of MMP-9 (-1562) CT (P = 0.001; OR = 1.44 (CI = 0.97–2.14)) and TT genotype (P = 0.05; OR = 2.6 (CI = 1.46–4.69)) were reported in preterm birth. Our findings suggest thattheMMP-9 plays an important role in contributing preterm labour and this can be used as a diagnostic tool during pregnancyen_US
dc.identifier.affiliationsDepartment of Pediatrics, King George’s Medical University, Lucknow 226 003, Indiaen_US
dc.identifier.citationPandey Monika, Awasthi Shally. Role of MMP-1, MMP-8 and MMP-9 gene polymorphisms in preterm birth. Journal of Genetics. 2020 Jan; 99: 1-7en_US
dc.identifier.issn0022-1333
dc.identifier.issn0973-7731
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/215563
dc.languageenen_US
dc.publisherIndian Academy of Sciencesen_US
dc.relation.volume99en_US
dc.source.urihttps://doi.org/10.1007/s12041-019-1161-7en_US
dc.subjectinfectionen_US
dc.subjectinflammationen_US
dc.subjectmatrix metalloproteinasesen_US
dc.subjectpolymorphismen_US
dc.subjectpreterm birthen_US
dc.titleRole of MMP-1, MMP-8 and MMP-9 gene polymorphisms in preterm birthen_US
dc.typeJournal Articleen_US
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