Role of MMP-1, MMP-8 and MMP-9 gene polymorphisms in preterm birth
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Date
2020-01
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Publisher
Indian Academy of Sciences
Abstract
Novel approaches to preterm births are underway building upon our prior discoveries and probing into unknown discovery pathways. The recent findings showed a high affinity of MMP-9 in serum and its polymorphisms for preterm birth. This study, which is a hospital-based case– control study, aims to investigate the association of MMP-1, MMP-8 and MMP-9 polymorphisms, and levels of MMP-9 in preterm birth. Increased level of MMP-9 was reported in cases as compared to control. The significant association of MMP-9 (-1562) CT (P = 0.001; OR = 1.44 (CI = 0.97–2.14)) and TT genotype (P = 0.05; OR = 2.6 (CI = 1.46–4.69)) were reported in preterm birth. Our findings suggest thattheMMP-9 plays an important role in contributing preterm labour and this can be used as a diagnostic tool during pregnancy
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Keywords
infection, inflammation, matrix metalloproteinases, polymorphism, preterm birth
Citation
Pandey Monika, Awasthi Shally. Role of MMP-1, MMP-8 and MMP-9 gene polymorphisms in preterm birth. Journal of Genetics. 2020 Jan; 99: 1-7