A retrospective study of adverse drug reactions in a tertiary care center

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dc.contributor.authorL., Ankithaen_US
dc.contributor.authorH., Rameshen_US
dc.date.accessioned2020-04-23T08:01:41Z
dc.date.available2020-04-23T08:01:41Z
dc.date.issued2020-04
dc.description.abstractBackground: Adverse drug reactions (ADRs) are a major concern in clinical practice. Reporting of ADRs either through health care professionals or the patients themselves is of utmost importance to give an accurate estimate of the prevalence, severity and preventability of ADRs. Present study was conducted to evaluate the prevalence of adverse drug reactions in a tertiary care hospital in Hubballi, Karnataka, India.Methods: This was a retrospective observational study, extending over 6 months (May 2019 to October 2019). A total of 124 cases comprising patients of either sex and age group ranging from 1month to 72 years were studied. The data was collected using CDSCO ADR reporting form. 揘aranjo抯 Assessment Scale� was used for causality assessment and severity assessment was done in accordance with 揌artwig and Siegel scale�.Results: The study showed majority of ADRs were from General Medicine department and affected skin and appendages (59%). Skin rashes 44 (31.7%) were found to be the most commonly reported ADRs most of them were with antimicrobials 67 (54%). After causality assessment 83 (66.9%) of the cases were classified as probable and 41 (33.1%) were classified as possible. Majority of serious ADRs were not preventable in our study.Conclusions: ADRs are a major cause of morbidity worldwide. Frequency of ADRs can be reduced by careful follow up and a robust hospital-based pharmacovigilance setup. Measures to improve detection and reporting of adverse drug reactions by all health care professionals is recommended.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Karnataka Institute of Medical Sciences, Hubballi, Karnataka, Indiaen_US
dc.identifier.citationL. Ankitha, H. Ramesh. A retrospective study of adverse drug reactions in a tertiary care center. International Journal of Basic & Clinical Pharmacology. 2020 Apr; 9(4): 611-615en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200579
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber4en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20201186en_US
dc.subjectAdverse drug reactionsen_US
dc.subjectCausalityen_US
dc.subjectPharmacovigilanceen_US
dc.subjectPreventabilityen_US
dc.subjectRetrospectiveen_US
dc.titleA retrospective study of adverse drug reactions in a tertiary care centeren_US
dc.typeJournal Articleen_US
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