Simvastatin and Its Role in Anti - Inflammation and Cancer Therapy: A Review

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dc.contributor.authorIzhar, Raafiahen_US
dc.contributor.authorAli, Gufranen_US
dc.contributor.authorAbidi, Syed Sibte Akbaren_US
dc.contributor.authorMahtab, Mohammaden_US
dc.date.accessioned2023-08-19T05:00:14Z
dc.date.available2023-08-19T05:00:14Z
dc.date.issued2022-06
dc.description.abstract3 - Hydroxy - 3 - methylglutaryl - coenzyme, a reductase inhibitors (statins) are widely used drugs to reduce lipid levels by inhibiting cholesterol biosynthesis. Simvastatin, a lipophilic statin is one of the most frequently prescribed statin drugs throughout th e world due to profound reductions in LDL - C with excellent tolerability, with very little risk of important adverse effects, to a lower extent. It also reduce triglycerides and increase high - density lipoprotein cholesterol levels. Beside this, studies on simvastatin have shown to exhibit numerous pleiotropic effects, has beneficial effect on endothelial function, smooth muscle cell function, haemostasis, vascular wall function, LDL oxidation, kidney diseases, inflammation and anticarcinogenic effects on ma ny types of cancer including prostate, breast hepatic and colon carcinoma. In this review, we present aen_US
dc.identifier.affiliationsDepartment of Biosciences, Jamia Millia Islamia, New Delhi, India.en_US
dc.identifier.affiliationsDepartment of Pharmacology, J.N. Medical College & Hospital, A.M.U., Aligarh, U.P., Indiaen_US
dc.identifier.affiliationsConsultant Physician and Diabetologist, Diabetes Care Clinic, Aligarh, U.P., Indiaen_US
dc.identifier.affiliationsIstituto di Biochimica e Biologia Cellulare, Consiglio Nazionale delle Ricerche, Naples, Italyen_US
dc.identifier.citationIzhar Raafiah, Ali Gufran, Abidi Syed Sibte Akbar, Mahtab Mohammad. Simvastatin and Its Role in Anti - Inflammation and Cancer Therapy: A Review. Indian Journal of Medical Research. 2022 Jun; 8(2): 1-7en_US
dc.identifier.issn2454-9894
dc.identifier.issn2454-9886
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/224064
dc.languageenen_US
dc.publisherIbn Sina Academy of Medieval Medicine & Sciencesen_US
dc.relation.issuenumber2en_US
dc.relation.volume8en_US
dc.source.urihttps://doi.org/10.21276/iabcr.20 2 2 . 8 . 2 . 1en_US
dc.subjectStatinsen_US
dc.subjectSimvastatinen_US
dc.subjectCVDen_US
dc.subjectInflammationen_US
dc.subjectCanceren_US
dc.titleSimvastatin and Its Role in Anti - Inflammation and Cancer Therapy: A Reviewen_US
dc.typeJournal Articleen_US
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