Prevalence of DQ2, DQ8 and DR4 Alleles in Iraqi Celiac Patients

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dc.contributor.authorHameed, Wasan Samien_US
dc.contributor.authorAbdul-Mehdi, Raad Jasimen_US
dc.contributor.authorTarish, Hashim Raheemen_US
dc.contributor.authorAlsherees, Hashim Ali Abdulameeren_US
dc.date.accessioned2019-11-16T07:25:37Z
dc.date.available2019-11-16T07:25:37Z
dc.date.issued2016-07
dc.description.abstractCeliac disease(CD) is a chronic small intestinal immune-mediated enteropathy precipitated by exposure to dietary gluten in genetically predisposed individuals, many environmental triggering factors are suggested to participate in its pathogenesis, CD is strongly concomitant with specific HLA class II genes known as HLA-DQ2 and HLA-DQ8 which present in 90-95% of celiac patients and the remaining (5-10%) bears DR4-DQ8 haplotype. Also non-HLA genes my influence susceptibility to the disease but their influence has not been confirmed yet. So that this study aims to determine the distribution of DQ2, DQ8, DR4and non DQ2/DQ8 among Iraqi celiac patients. Sample of 80 Iraqi celiac patients (tTg-A,tTg-G and AGA positive)  has been chosen from all suspected patients who attending to Al-Suder- Medical city during the period of  April  2015 to  November 2015, blood samples were obtained from those patients and send for DNA extraction and HLA typing by RT-PCR. The results showed that 70% (56) patients were females and 30% (24) were males, also 37.5% from those patients were lies between 1-10 years old. HLA typing showed that 77.5% of those were had DQ2 genotyping, 7.5% were had D82 genotyping, 10% were had DR4-DQ8 genotyping and 5% were had non DQ2/DQ8 genotyping.en_US
dc.identifier.affiliationsAssist. Prof. Immunology, Department of Microbiology, College of Medicine/University of Kufaen_US
dc.identifier.affiliationsMed. Tech., Ph.D Stud., Department of Microbiology, College of Medicine/University of Kufa.en_US
dc.identifier.affiliationsProf. Microbiology, Head of Department of Microbiology, College of Medicine/ University of Kufa.en_US
dc.identifier.affiliationsAssist. Lecture, Department of Microbiology, College of Medicine/University of Kufa.en_US
dc.identifier.citationHameed Wasan Sami, Abdul-Mehdi Raad Jasim, Tarish Hashim Raheem, Alsherees Hashim Ali Abdulameer. Prevalence of DQ2, DQ8 and DR4 Alleles in Iraqi Celiac Patients. International Archives of BioMedical and Clinical Research. 2016 Jul-Sep; 2(3): 118-121en_US
dc.identifier.issn2454-9894
dc.identifier.issn2454-9886
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/184334
dc.languageenen_US
dc.publisherIbn Sina Academy of Medieval Medicine & Sciencesen_US
dc.relation.issuenumber3en_US
dc.relation.volume2en_US
dc.source.urihttps://doi.org/10.21276/iabcr.2016.2.3.30en_US
dc.subjectCeliac diseaseen_US
dc.subjectDQ2en_US
dc.subjectDQ8en_US
dc.subjectDR4en_US
dc.titlePrevalence of DQ2, DQ8 and DR4 Alleles in Iraqi Celiac Patientsen_US
dc.typeJournal Articleen_US
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