Expression of CK19, CD56, and Galectin-3 Tumor Markers in Different Types of Thyroid Carcinoma

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dc.contributor.authorAlshammari, Dinaen_US
dc.contributor.authorSaadaldin, Afraen_US
dc.contributor.authorElasbali, Abdelbaset Mohameden_US
dc.contributor.authorD., Fawazen_US
dc.contributor.authorAlshammrien_US
dc.contributor.authorAlmansi, Waliden_US
dc.contributor.authorAhmed, Hussain Gadelkarimen_US
dc.date.accessioned2020-09-24T07:52:00Z
dc.date.available2020-09-24T07:52:00Z
dc.date.issued2019-06
dc.description.abstractBackground: Thyroid disorders represent a major problem in Saudi Arabia, particularly in the northern part of the country. The objective of the current study was to investigate the immunohistochemical expression of CK19, CD56, and Gal-3 in a series of Saudi patients with thyroid carcinoma in Northern Saudi Arabia (Hail) region. Methodology: This is a retrospective study, investigated 50 formalin-fixed paraffin wax tissue blocks with a confirmed diagnosis of thyroid carcinoma from Northern Saudi Arabia. Immunohistochemistry demonstration was for CK19, CD56, and Gal-3 markers applying Avidin-Biotin method. Results: Out of the 50 patients, 45(90%) were females and 5(10%) were males, aged 13-70 years old with a mean age of 43 years. CK19 was positively expressed in 74% of the thyroid carcinoma. Positive CD56 expression was demonstrated in 45.7%, 58.3%, and 100% of the papillary, follicular and undifferentiated thyroid carcinomas, correspondingly. Positive Galectin-3 expression was demonstrated in 71.4%, 58.3%, and 100% of the papillary, follicular and undifferentiated thyroid carcinomas, correspondingly. Conclusion: Papillary thyroid carcinoma is the most common thyroid cancer in Northern Saudi Arabia. Females represent more than 90% of the cases of the thyroid carcinoma in Northern Saudi Arabia. CK19, CD56, and Gal-3 are useful for the assessment of thyroid carcinoma.en_US
dc.identifier.affiliationsDepartment of Clinical Laboratory Sciences, College of Applied Medical Science, University of Hail, Hail, Saudi Arabiaen_US
dc.identifier.affiliationsDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Qurayyat, Saudi Arabiaen_US
dc.identifier.affiliationsDepartment of Pathology, College of Medicine, University of Hail, Hail, Saudi Arabiaen_US
dc.identifier.citationAlshammari Dina, Saadaldin Afra, Elasbali Abdelbaset Mohamed, D. Fawaz, Alshammri, Almansi Walid, Ahmed Hussain Gadelkarim. Expression of CK19, CD56, and Galectin-3 Tumor Markers in Different Types of Thyroid Carcinoma. International Journal of Medical Research & Health Sciences. 2019 Jun; 8(6): 125-134en_US
dc.identifier.issn2319-5886
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/204956
dc.languageenen_US
dc.publisherSumathi Publicationsen_US
dc.relation.issuenumber6en_US
dc.relation.volume8en_US
dc.source.urihttps://www.ijmrhs.com/abstract/expression-of-ck19-cd56-and-galectin3-tumor-markers-in-different-types-of-thyroid-carcinoma-18428.htmlen_US
dc.subjectThyroid canceren_US
dc.subjectPapillary carcinomaen_US
dc.subjectFollicular carcinomaen_US
dc.subjectSaudi Arabiaen_US
dc.subjectCK19en_US
dc.subjectCD56en_US
dc.subjectGal-3en_US
dc.titleExpression of CK19, CD56, and Galectin-3 Tumor Markers in Different Types of Thyroid Carcinomaen_US
dc.typeJournal Articleen_US
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