Air Way Bacterial Colonization in COPD Patients at Stable and the Exacerbated States

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dc.contributor.authorAbdelraheem, Wedad M.en_US
dc.contributor.authorMohamed, Ebtisam S.en_US
dc.contributor.authorAbdelghany, Elham A.en_US
dc.contributor.authorEmam, Rasha M.en_US
dc.contributor.authorMohamed, Manar S.en_US
dc.date.accessioned2020-09-24T07:52:01Z
dc.date.available2020-09-24T07:52:01Z
dc.date.issued2019-01
dc.description.abstractObjectives: The aim of this study was to investigate the prevalence and load of airway bacteria in chronic obstructive pulmonary disease (COPD) patients and to detect the antibiotic susceptibility pattern of the isolated strains. Methods: The current study included 50 COPD patients. Paired sputum samples were taken from all patients, one at the exacerbation state and the other at the stable state. Identification of bacterial species was done using standard microbiological techniques and PCR. Results: There were 41 samples out of 50 (82%) positive for bacteria at exacerbation compared with 12 samples out of 50 (24%) positive for bacteria (either by culture or PCR or both) at stable state samples (p=0.001). The most commonly detected species was H. influenza and S. pneumoniae. There were a total of 27 bacterial species detected by PCR not detected by culture and only 4 bacterial species detected by culture not detected by PCR (p=0.001). Isolated strains show a high resistance pattern to the tested antibiotics and multi drug resistant strains were detected. Conclusions: This study has shown that airway bacterial prevalence and load increase at COPD exacerbations, and there is a significant relationship between lower airway bacterial colonization and COPD.en_US
dc.identifier.affiliationsDepartment of Medical Microbiology and Immunology, Minia University, Minia, Egypten_US
dc.identifier.affiliationsDepartment of Chest Diseases and Tuberculosis, Minia University, Minia, Egypten_US
dc.identifier.affiliationsDepartment of Internal Medicine, Deraya University, Minia, Egypten_US
dc.identifier.citationAbdelraheem Wedad M., Mohamed Ebtisam S., Abdelghany Elham A., Emam Rasha M., Mohamed Manar S.. Air Way Bacterial Colonization in COPD Patients at Stable and the Exacerbated States. International Journal of Medical Research & Health Sciences. 2019 Jan; 8(1): 94-100en_US
dc.identifier.issn2319-5886
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/204961
dc.languageenen_US
dc.publisherSumathi Publicationsen_US
dc.relation.issuenumber1en_US
dc.relation.volume8en_US
dc.source.urihttps://www.ijmrhs.com/abstract/air-way-bacterial-colonization-in-copd-patients-at-stable-and-the-exacerbated-states-15507.htmlen_US
dc.subjectCOPDen_US
dc.subjectStableen_US
dc.subjectExacerbationen_US
dc.subjectCultureen_US
dc.subjectPCRen_US
dc.titleAir Way Bacterial Colonization in COPD Patients at Stable and the Exacerbated Statesen_US
dc.typeJournal Articleen_US
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