Neuroprotective Effect Of Methanolic Extract Of Sargassum Wightii On Haloperidol Induced Catalepsy And Tardive Dyskinesia In Albino Rats

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dc.contributor.authorRout, S.en_US
dc.contributor.authorRath, B.en_US
dc.contributor.authorBhattamisra, S. K.en_US
dc.contributor.authorKumar, A.en_US
dc.contributor.authorRath, S.en_US
dc.date.accessioned2020-09-24T08:01:45Z
dc.date.available2020-09-24T08:01:45Z
dc.date.issued2020-03
dc.description.abstractObjective: The present study was designed to evaluate the neuroprotective effect of methanolic extract of Sargassum wightii on haloperidol-induced catalepsy and tardive dyskinesia in Wistar albino rats. Methods: In this study, thirty Wistar albino rats were randomly divided into six groups. Gr-I served as control. Haloperidol (1 mg/kg intraperitoneally) was administered to rats of Gr-II to Gr-V for twenty-one consecutive days to induce catalepsy and tardive dyskinesia. Animals of Gr-II to Gr-V were orally administered with vehicle, levodopa carbidopa combination (30 mg/kg), Sargassum extract 200 and 400 mg/kg respectively. All the drugs and vehicles were given orally one hour before haloperidol injection for twenty one consecutive days. The cataleptic scores were recorded using standard bar test. Tardive dyskinesia was assessed in terms of vacuous chewing movement (VCM) and tongue protrusion (TP) scores. After behavioural testing, all animals were sacrificed on twenty-second day and various biochemical parameters like MDA, SOD and GSH were estimated in brain tissue. Results: Chronic administration of haloperidol significantly increased cataleptic scores, VCM and TP scores. (p<0.001) Sargassum wightii extract (400 mg/kg) significantly inhibited haloperidol-induced catalepsy, VCM and TP (p<0.001) Haloperidol increased MDA and decreased SOD and GSH in brain tissue to a highly significant extent (p<0.001) Sargassum extract at 400 mg/kg also significantly reversed the haloperidol-induced alteration in brain oxidative stress markers. Conclusion: Sargassum wightii inhibits haloperidol-induced catalepsy and tardive dyskinesia. Thus it may be used as a unique therapeutic adjunct for the prevention of neuroleptic-induced extrapyramidal symptoms, however, it has to be explored more.en_US
dc.identifier.affiliationsPharmacology, Roland Institute of Pharmaceutical Sciences, Berhampur, Odishaen_US
dc.identifier.affiliationsPharmacology Fakir Mohan Medical College, Balasore, Odishaen_US
dc.identifier.affiliationsPharmacology, Roland Institute of Pharmaceutical Sciences, Berhampur, Odishaen_US
dc.identifier.affiliationsPharmaceutical Chemistry, Roland Institute of Pharmaceutical Sciences, Berhampur, Odishaen_US
dc.identifier.affiliationsAnatomy, MKCG Medical College, Berhampur Odishaen_US
dc.identifier.citationRout S., Rath B., Bhattamisra S. K., Kumar A., Rath S.. Neuroprotective Effect Of Methanolic Extract Of Sargassum Wightii On Haloperidol Induced Catalepsy And Tardive Dyskinesia In Albino Rats. International Journal of Pharmacy and Pharmaceutical Sciences. 2020 Mar; 12(3): 1-6en_US
dc.identifier.issn0975-1491
dc.identifier.issn2656-0097
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/206055
dc.languageenen_US
dc.publisherInnovare Academic Sciences Pvt. Ltd.en_US
dc.relation.issuenumber3en_US
dc.relation.volume12en_US
dc.source.urihttps://doi.org/10.22159/ijpps.2020v12i3.36518en_US
dc.subjectSargassum wightiien_US
dc.subjectCatalepsyen_US
dc.subjectTardive dyskinesiaen_US
dc.subjectOxidative stressen_US
dc.subjectAlbino raten_US
dc.titleNeuroprotective Effect Of Methanolic Extract Of Sargassum Wightii On Haloperidol Induced Catalepsy And Tardive Dyskinesia In Albino Ratsen_US
dc.typeJournal Articleen_US
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