Immunohistochemical demonstration of mycobacterial antigens in intracranial tuberculoma.

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dc.contributor.authorRadhakrishnan, V Ven_US
dc.contributor.authorMathai, Aen_US
dc.contributor.authorRadhakrishnan, N Sen_US
dc.contributor.authorRout, Den_US
dc.contributor.authorSehgal, Sen_US
dc.date.accessioned2009-05-28T15:48:44Z
dc.date.available2009-05-28T15:48:44Z
dc.date.issued1991-07-01en_US
dc.description.abstractMycobacterial antigens have been demonstrated immunohistochemically in the paraffin sections of 10 intracranial tuberculous granulomas and the results were compared with the detection of acid fast bacilli by conventional Ziehl-Neelsen method. In none of the 10 specimens, acid fast bacilli were demonstrated while mycobacterial antigens were characterised as diffusely staining granular brownish-pink material within the cytoplasm of giant cells and macrophages. In 14 specimens of granulomatous lesions due to non-tuberculous aetiology, immunohistochemical stains were negative for mycobacterial antigen. Thus demonstration of mycobacterial antigen will be not only useful in establishing mycobacterial aetiology of a caseating intracranial granuloma but also can be used as an alternative method to the conventional Ziehl-Neelsen method.en_US
dc.description.affiliationDepartment of Pathology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.en_US
dc.identifier.citationRadhakrishnan VV, Mathai A, Radhakrishnan NS, Rout D, Sehgal S. Immunohistochemical demonstration of mycobacterial antigens in intracranial tuberculoma. Indian Journal of Experimental Biology. 1991 Jul; 29(7): 641-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/62444
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAntigens, Bacterial --analysisen_US
dc.subject.meshBrain Diseases --diagnosisen_US
dc.subject.meshGranuloma --immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoenzyme Techniquesen_US
dc.subject.meshMycobacterium tuberculosis --immunologyen_US
dc.subject.meshStaining and Labelingen_US
dc.subject.meshTuberculoma --diagnosisen_US
dc.titleImmunohistochemical demonstration of mycobacterial antigens in intracranial tuberculoma.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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