Hypolipidemic and antioxidant activity of ethanolic extract of Symplocos racemosa Roxb. in hyperlipidemic rats: An evidence of participation of oxidative stress in hyperlipidemia.

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dc.contributor.authorDurkar, A M
dc.contributor.authorPatil, R R
dc.contributor.authorNaik, S R
dc.date.accessioned2014-04-29T09:27:02Z
dc.date.available2014-04-29T09:27:02Z
dc.date.issued2014-01
dc.description.abstractHypolipidemic and antioxidant activity profiles of ethanolic extracts of Symplocos racemosa (EESR) were studied by triton-WR1339 (acute) and high fat diet induced (chronic) hyperlipidemic rat models. In both the models, a significant increase in total cholesterol (TC), triglycerides (TG), very low density lipoproteins (VLDL), low density lipoproteins (LDL) and decrease in high density lipoproteins (HDL) in serum were observed. EESR (200 and 400 mg/kg) and simvastatin (10 mg/kg) administered orally reduced the elevated serum lipids (TC, TG, VLDL, LDL), restored the decreased HDL and improved the atherogenic index. In high fat diet induced hyperlipidemic model, EESR treatment prevented the increased formation of malondialdehyde (MDA) in liver, restored the depleted liver antioxidants, glutathione, superoxide dismutase, catalase significantly. The increased liver cholesterol, HMG-CoA reductase activity and body weight of hyperlipidemic rats were significantly reduced by EESR treatment. The EESR inhibited HMG-CoA reductase, a rate limiting enzyme in cholesterol biosynthesis, thereby causing hypolipidemic effects. EESR treatment also improved histoarchitecture of hepatocytes in hyperlipidemic rats. Experimental findings demonstrated anti-hyperlipidemic and antioxidant activity of EESR, which may be directly or indirectly related to its antioxidant activity. The hypolipidemic activity of EESR may be due to the presence of flavonoids phenolic compounds, phenolic glycosides and steroids.en_US
dc.identifier.citationDurkar A M, Patil R R, Naik S R. Hypolipidemic and antioxidant activity of ethanolic extract of Symplocos racemosa Roxb. in hyperlipidemic rats: An evidence of participation of oxidative stress in hyperlipidemia. Indian Journal of Experimental Biology. 2014 Jan; 52(1): 36-45.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/150330
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/25147en_US
dc.subjectHyperlipidemiaen_US
dc.subjectHypolipidemiaen_US
dc.subjectPlant-antioxidantsen_US
dc.subjectSymplocos racemosaen_US
dc.subject.meshAnimals
dc.subject.meshAntioxidants --administration & dosage
dc.subject.meshAntioxidants --chemistry
dc.subject.meshCholesterol --blood
dc.subject.meshCholesterol, HDL --blood
dc.subject.meshCholesterol, LDL --blood
dc.subject.meshDiet, High-Fat
dc.subject.meshEricaceae --chemistry
dc.subject.meshHumans
dc.subject.meshHyperlipidemias --drug therapy
dc.subject.meshHyperlipidemias --metabolism
dc.subject.meshHyperlipidemias --pathology
dc.subject.meshHypolipidemic Agents --administration & dosage
dc.subject.meshHypolipidemic Agents --chemistry
dc.subject.meshLipoproteins, VLDL --blood
dc.subject.meshMale
dc.subject.meshOxidative Stress --drug effects
dc.subject.meshPlant Extracts --administration & dosage
dc.subject.meshPlant Extracts --chemistry
dc.subject.meshRats
dc.subject.meshSuperoxide Dismutase --metabolism
dc.titleHypolipidemic and antioxidant activity of ethanolic extract of Symplocos racemosa Roxb. in hyperlipidemic rats: An evidence of participation of oxidative stress in hyperlipidemia.en_US
dc.typeArticleen_US
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