A serious warning: A case report on localized amyloidosis of the oral cavity
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Date
2025-03
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Wolters Kluwer - Medknow
Abstract
Amyloidosis is a relatively rare condition with an array of complex pathophysiology. Localized amyloidosis is a rare and benign condition that practically never results in any clinical repercussions in the head and neck area. Multiple soft nodules of the tongue, lip, and cheek are the most commonly described defining characteristics of localized oral amyloidosis. These nodules originate due to the proliferation of abnormally folded protein aggregates in the body’s extracellular tissue compartments, which destroy organ structure and function. Herein, we address the case of a female infant aged one with a smooth nodule in the labial mucosa who was diagnosed with primary localized amyloidosis. When a patient is diagnosed with amyloidosis of the oral mucosa, the possibility of systemic amyloidosis or an underlying plasma cell dyscrasia must be ruled out. Surgical treatment may be beneficial for eliminating any functional impairment if primary localized amyloidosis is established.
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Keywords
Amyloidosis, kappa chains, lambda chains, serum amyloid p component
Citation
John S, Subba P, Aramugam A, Gupta S, Khanna R. A serious warning: A case report on localized amyloidosis of the oral cavity. Indian Journal of Pathology & Microbiology. 2025 Mar; 68(1): 212-215