Non-Familial Hereditary Hemorrhagic Telangiectasia In A Middle-Aged South Asian Male- A Case Report

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dc.contributor.authorBharadwaj, Sen_US
dc.contributor.authorPatel, Yen_US
dc.contributor.authorShah, Aen_US
dc.contributor.authorPatel, Y.en_US
dc.date.accessioned2024-12-02T11:15:58Z
dc.date.available2024-12-02T11:15:58Z
dc.date.issued2024-01
dc.description.abstractBackground:Hereditary Hemorrhagic Telangiectasia (HHT) also known as Osler-Weber-Rendu syndrome is an autosomal dominant disease with a prevalence of 1 in 5000 to 10,000. It is characterized by mucocutaneous and visceral telangiectasias with multiorgan involvement-resulting in anemia causing a continuous blood transfusion requirement.Case Description:A 45-year-old diabetic male with a history of recurrent epistaxis since 6 years of age presented with anemic heart failure. Upper GI endoscopy and contrast-enhanced CT abdomen were suggestive of multiple telangiectasias in the oral cavity, oropharynx, and jejunal angiodysplasias with duodenal erosions. The patient was diagnosed with HHT based on three out of four Curacao criteria-Recurrent spontaneous epistaxis, Telangiectasias, and Visceral lesions. The patient was treated with oral Thalidomide and Packed Red Cell transfusions. Epistaxis was conservatively managed with topical medications while the patient underwent Argon Plasma Coagulation for gastrointestinal bleeding. According to hematological opinion, Bevacizumab therapy was planned but due to non-affordability, the family decided to continue with the existing treatment and the patient succumbed a month later. Early diagnosis with a low threshold of suspicion is important to improve the quality of life and life expectancy for this disease.en_US
dc.identifier.affiliationsSecond Year Resident, Department of General Medicine, Smt. N.H.L. Municipal Medical College, Ahmedabad, 380006, Indiaen_US
dc.identifier.affiliationsSecond Year Resident, Department of General Medicine, Smt. N.H.L. Municipal Medical College, Ahmedabad, 380006, Indiaen_US
dc.identifier.affiliationsPost Intern, Department of General Medicine, Smt. N.H.L. Municipal Medical College, Ahmedabad, 380006, Indiaen_US
dc.identifier.affiliationsPost Intern, Department of General Medicine, Smt. N.H.L. Municipal Medical College, Ahmedabad, 380006, Indiaen_US
dc.identifier.citationBharadwaj S, Patel Y, Shah A, Patel Y.. Non-Familial Hereditary Hemorrhagic Telangiectasia In A Middle-Aged South Asian Male- A Case Report . Tropical Gastroenterology. 2024 Jan; 15(1): 57-60en_US
dc.identifier.issn0975-9840
dc.identifier.issn2230-9969
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/239957
dc.languageenen_US
dc.publisherAssociation of Health Professionals and Health Educatorsen_US
dc.relation.issuenumber1en_US
dc.relation.volume15en_US
dc.source.urihttps://doi.org/10.70284/njirm.v15i1.4070en_US
dc.subjectBevacizumaben_US
dc.subjectCuracao Criteriaen_US
dc.subjectHereditary Hemorrhagic Telangiectasiaen_US
dc.subjectOsler-Weber-Rendu Syndromeen_US
dc.subjectRecurrent Epistaxisen_US
dc.subjectThalidomideen_US
dc.titleNon-Familial Hereditary Hemorrhagic Telangiectasia In A Middle-Aged South Asian Male- A Case Reporten_US
dc.typeJournal Articleen_US
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