In-vitro study of formulation and evaluation of nanosuspension of tamoxifen

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dc.contributor.authorReddy, Somasekhar M.en_US
dc.contributor.authorSriganth, Navispaul N.en_US
dc.contributor.authorKumar, Chandra S.en_US
dc.contributor.authorGursale, Santosh C.en_US
dc.contributor.authorRagavan, Vijay V.en_US
dc.date.accessioned2020-04-23T07:49:33Z
dc.date.available2020-04-23T07:49:33Z
dc.date.issued2018-05
dc.description.abstractBackground: Nanosuspension technology has been developed as a promising candidate for efficient delivery of hydrophobic drugs. It could maintain the required crystalline state of the drug with reduced particle size, leading to an increased reporting on dissolution rate and therefore improved bioavailability.Methods: In this paper, we report on the preparation of Tamoxifen nanosuspension by high-pressure homogenization (HPH). The aim is to obtain a stable nanosuspension with an increased drug saturation solubility and dissolution velocity. The morphology and particle size distribution of the modified nanosuspensions were characterized by the means of several analyses that included: transmission electron microscopy (TEM), polarized light microscopy (PLM), scanning electron microscopy, differential scanning calorimetry (DSC) and powder X- ray diffractometry (XRD).Results: HPH was employed to produce aqueous drug nanosuspensions with fine solubility and dissolution properties, which render the produced particles stable up to one month. In addition, the prepared nanosuspensions possessed a high drug-loading efficiency (10%). The recoded zeta potential values (? -27 mV) indicated that the prepared nanosuspensions possess a higher degree of long-term stability. TEM data showed narrow size distribution with average size 322.7 nm. Morphologically, as indicated from results, the produced nanosuspensions have a homogenous distribution even after redispersion, indicating the stability of the product.Conclusions: It was possible to obtain Tamoxifen nanosuspensions with fine solubility and dissolution properties. Nanosuspensions possessed a high drug- loading (10%), which could reduce the dosage administration and gastrointestinal side effects. HPH can be employed to produce aqueous drug nanosuspensions that are stable up to one month. Aqueous nanosuspension can be converted to dry nanocrystals by lyophilization which offer superior physicochemical properties.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Bhaskara Medical College, Moinabad, Rangaredy, Hyderabad, Telangana, Indiaen_US
dc.identifier.affiliationsDepartment of EEE, Saveetha School of Engineering, Thandalam Chennai, Tamilnadu, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, ESIC, Sanath Nagar, Hyderabad, Telangana, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, B.K.L. Walawalkar Rural Medical College, Sawarde, Ratnagiri, Maharashtra, Indiaen_US
dc.identifier.affiliationsDirector, Saveetha University, Thandalam, Chennai, Tamilnadu, Indiaen_US
dc.identifier.citationReddy Somasekhar M., Sriganth Navispaul N., Kumar Chandra S., Gursale Santosh C., Ragavan Vijay V.. In-vitro study of formulation and evaluation of nanosuspension of tamoxifen. International Journal of Basic & Clinical Pharmacology. 2018 May; 7(5): 926-934en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/199680
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber5en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20181637en_US
dc.subjectElectron microscopyen_US
dc.subjectNanosuspensionen_US
dc.subjectTamoxifenen_US
dc.subjectTransmissionen_US
dc.titleIn-vitro study of formulation and evaluation of nanosuspension of tamoxifenen_US
dc.typeJournal Articleen_US
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