A Simple Computed Tomography Scoring System to Predict Histological Malignancy of Solitary Fibrous Tumors of the Pleura.

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dc.contributor.authorHélage, Siegfried
dc.contributor.authorRevel, Marie Pierre
dc.contributor.authorAlifano, Marco
dc.contributor.authorLupo, Audrey Mansuet
dc.contributor.authorVadrot, Dominique
dc.date.accessioned2016-03-17T09:37:51Z
dc.date.available2016-03-17T09:37:51Z
dc.date.issued2015
dc.description.abstractPurpose: The aim of the present study was to define the very first score enabling discrimination between benign and malignant solitary fibrous tumors of the pleura (SFTPs), on the basis of reliable preoperative CT features. Methods: Between December 2004 and November 2012, 56 patients underwent complete resection for SFTP at six institutes. CT scans were reviewed retrospectively, and a diagnostic scoring system for predicting malignant SFTP preoperatively was designed. Results: Univariate analysis revealed seven significant predictors of malignant SFTP: tumor size ≥ 10 cm (p=0.002), tumor heterogeneity spontaneously (p=0.019) or after contrast medium injection (p=0.029), existence of intratumoral fluid density areas (p=0.011), a pleural effusion (p=0.01), measurable (diameter >1 mm) intratumoral vessels (p=0.019), a hypervascular character (visible intratumoral vessels and/or intense enhancement) (p=0.001). A scoring system based on these seven CT features, each assigned 1 point, and with a cut-off of 4 points, could predict malignant SFTP with a specificity of 85% and a sensitivity of 48%. Conclusion: Our scoring system using seven CT features (tumor size ≥ 10 cm, tumor heterogeneity with or without contrast injection, intratumoral fluid density areas, pleural effusion, measurable intratumoral vessels, and a hypervascular character of the tumor) may be helpful for predicting histological malignancy of solitary fibrous tumors of the pleura.en_US
dc.identifier.citationHélage Siegfried, Revel Marie Pierre, Alifano Marco, Lupo Audrey Mansuet, Vadrot Dominique. A Simple Computed Tomography Scoring System to Predict Histological Malignancy of Solitary Fibrous Tumors of the Pleura. British Journal of Medicine and Medical Research. 2015; 5(10): 1301-1308.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/176110
dc.language.isoenen_US
dc.source.urihttps://sciencedomain.org/abstract/6795en_US
dc.subjectSolitary fibrous tumoren_US
dc.subjectSFTen_US
dc.subjectPleuraen_US
dc.subjectpleural fibromaen_US
dc.subjectCT scanen_US
dc.subjectscoring systemen_US
dc.titleA Simple Computed Tomography Scoring System to Predict Histological Malignancy of Solitary Fibrous Tumors of the Pleura.en_US
dc.typeArticleen_US
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