Adrenergic influence of uterine muscle contractions stimulated by a glycoside from the root of Dalbergia saxatilis.

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dc.contributor.authorUchendu, C Nen_US
dc.contributor.authorLeek, B Fen_US
dc.date.accessioned2009-05-28T16:34:10Z
dc.date.available2009-05-28T16:34:10Z
dc.date.issued1999-04-21en_US
dc.description.abstractThe mechanism of uterine muscle contraction stimulated by a triterpenoid glycoside (dalsaxin) isolated from the root of D. saxatilis was investigated by in vitro methods in the rat. Dalsaxin caused a dose-related increase in uterine muscle contraction. The contraction was single and transient and was abolished by moderate doses of isoprenaline (1.80 nmol-0.40 mumol) and salbutamol (0.13-25 mumol). Adrenaline (9.10 nmol) also caused a reversible decrease (92.6%; P < 0.01) in myometrial contraction stimulated by this glycoside (0.24 mg/ml). Uterine muscle responses to dalsaxin (0.24 mg/ml) were enhanced by the beta-adrenergic receptor antagonist, propranolol, in a dose related manner. Atipamezole (1.50 ng/ml) but not prazosin (7.72 nmol-15.60 nmol) substantially reduced (80%; P < 0.01) myometrial contractions induced by this uterine spasmogen. The results suggest that dalsaxin enhances uterine muscle contraction by stimulating post junctional alpha 2-adrenergic receptors, presumably by inhibiting plasma membrane adenylate cyclase system and its associated increase in intracellular cAMP content.en_US
dc.description.affiliationDepartment of Veterinary Physiology & Pharmacology, University of Nigeria, Nsukka, Nigeria.en_US
dc.identifier.citationUchendu CN, Leek BF. Adrenergic influence of uterine muscle contractions stimulated by a glycoside from the root of Dalbergia saxatilis. Indian Journal of Experimental Biology. 1999 Apr; 37(4): 350-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/63397
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAdrenergic alpha-Agonists --isolation & purificationen_US
dc.subject.meshAdrenergic alpha-Antagonists --pharmacologyen_US
dc.subject.meshAdrenergic beta-Agonists --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshFabaceae --chemistryen_US
dc.subject.meshFemaleen_US
dc.subject.meshPlant Roots --chemistryen_US
dc.subject.meshPlants, Medicinal --chemistryen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshUterine Contraction --drug effectsen_US
dc.titleAdrenergic influence of uterine muscle contractions stimulated by a glycoside from the root of Dalbergia saxatilis.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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