Effects of the Hydroalcoholic Extract of Passiflora edulis on Anxiety Induced by Sub-acute Immobilization Stress

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dc.contributor.authorEspoir, Ayissi Mbomo Rigoberten_US
dc.contributor.authorAntoine, Kandeda Kavayeen_US
dc.contributor.authorMoto, Okomolo Fleur Clarisseen_US
dc.contributor.authorNanga, Léopold Didieren_US
dc.contributor.authorDjangou, Siebatcheu Sandrine Lindaen_US
dc.contributor.authorDimo, Théophileen_US
dc.date.accessioned2020-10-16T08:53:33Z
dc.date.available2020-10-16T08:53:33Z
dc.date.issued2020-04
dc.description.abstractAims:This study was carried out to assess the anxiolytic effects of the hydroalcoholic extract of P. edulis.Place and Duration of Study:Animal Physiology Laboratory of the Higher Teachers’ Training College, Animal Physiology Laboratory of the Faculty of Sciences , University of Yaoundé I, from November 2017 toAugust 2018.Methodology: Anxiety was induced to mice by thesub-acute immobilization stress. After 11 days treatment, behavioural parameters were assessed using Elevated Plus Maze (EPM) and Open Field (OF), then biochemical parameters (MDA, GSH, SOD, catalase, GABA, GABA-T and 5-HT) were estimated.Results:The results show that treatment with P. edulisat doses 100 and 200 mg/kg significantly increased open arms entries and time, while reducing closed arms entries and time in the EPM test. Lines crossed as well as passages through the centre and the centre time were significantly increased in the OF test. It is suggested that P.edulis would protect against anxiety and this effect probably linked to its ability to fight oxidative stress and counteract hyperexcitability by potentiating the GABA action. The more effective dose, 100 mg/kg significantly (P<0.01) increased to 4.44 ± 0.24 μmol/g the activity of GSH. In mice treated with dose 100 mg/kg, the extract induced a significant decrease of three oxidative stress markers including MDA, catalase and SOD to0.22 ± 0.01 μmol/g, 1.05± 0.15 mmolH2O2/min/g; and 19.46±0.00 unit/min/mg respectively when compared to the negative control. Animals treated with P. edulis100mg/kg presented a significantincrease level (P<0.001) of GABA and 5-HT up to 4.62 ± 0.28 and μg/g and 31.47 ± 1.58 ng/ml respectively. GABA-T activity was also impacted by the treatment with P. edulis, since the value of GABA-T activity of 1.27 ± 0.10 in the negative control significantly (P<0.001) decreased to 0.37± 0.00 in the group treated with dose 100 mg/kg. Conclusion:The beneficial effects of this extract observed in this study justify the empirical use of P. edulisin the treatment of head ache and insomniaen_US
dc.identifier.affiliationsDepartment of Biological Sciences, Higher Teacher’s Training College, University of Yaoundé I, Yaoundé, Cameroonen_US
dc.identifier.affiliationsDepartment of Animal Biology and Physiology, Faculty of Sciences, University of Yaoundé I, Yaoundé, Cameroonen_US
dc.identifier.affiliationsDepartment of Biological Sciences, Higher Teacher’s Training College, University of Yaoundé I, Yaoundé, Cameroonen_US
dc.identifier.affiliationsDepartment of Animal Biology and Physiology, Faculty of Sciences, University of Yaoundé I, Yaoundé, Cameroonen_US
dc.identifier.affiliationsDepartment of Pharmacy, Higher Institute of Health Sciences, University of the Mountains, Baganté, Cameroonen_US
dc.identifier.affiliationsDepartment of Animal Biology and Physiology, Faculty of Sciences, University of Yaoundé I, Yaoundé, Cameroonen_US
dc.identifier.citationEspoir Ayissi Mbomo Rigobert, Antoine Kandeda Kavaye, Moto Okomolo Fleur Clarisse, Nanga Léopold Didier, Djangou Siebatcheu Sandrine Linda, Dimo Théophile. Effects of the Hydroalcoholic Extract of Passiflora edulis on Anxiety Induced by Sub-acute Immobilization Stress. Journal of Advances in Medicine and Medical Research. 2020 Apr; 32(5): 159-169en_US
dc.identifier.issn2456-8899
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210355
dc.languageenen_US
dc.publisherSCIENCEDOMAIN internationalen_US
dc.relation.issuenumber5en_US
dc.relation.volume32en_US
dc.source.urihttps://dx.doi.org//10.9734/JAMMR/2020/v32i530425en_US
dc.subjectAnxietyen_US
dc.subjectPassiflora edulisen_US
dc.subjectimmobilisation stressen_US
dc.subjectoxidative stress markersen_US
dc.subjectNeurotransmittersen_US
dc.titleEffects of the Hydroalcoholic Extract of Passiflora edulis on Anxiety Induced by Sub-acute Immobilization Stressen_US
dc.typeJournal Articleen_US
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