Schwann cells promote neurite outgrowth of dorsal root ganglion neurons through secretion of nerve growth factor.

Simple item page
dc.contributor.authorHu, Jianguo
dc.contributor.authorZhou, Jiansheng
dc.contributor.authorLi, Xingwu
dc.contributor.authorWang, Fengchao
dc.contributor.authorLü, Hezuo
dc.date.accessioned2013-02-14T05:54:38Z
dc.date.available2013-02-14T05:54:38Z
dc.date.issued2011-03
dc.description.abstractThe transplantation of Schwann cells (SCs) could successfully promote axonal regeneration. This is likely to attribute to the adhesion molecules expression and growth factors secretion of SCs. But which factor(s) play a key role has not been precisely studied. In this study, an outgrowth assay using dorsal root ganglia (DRG) neuron-SC co-culture system in vitro was performed. Co-culture of SCs or application of SC-conditioned medium (CM) substantially and significantly increased DRG neurite outgrowth. Further, nerve growth factor and NGF receptor (TrkA) mRNA were highly expressed in Schwann cells and DRG neuron, respectively. The high concentration of NGF protein was detected in SC-CM. When K-252a, a specific inhibitor of NGF receptor was added, DRG neurite outgrowth was significantly decreased in a concentration-dependent manner. These data strongly suggest that SCs play important roles in neurite outgrowth of DRG neurons by secreted NGF.en_US
dc.identifier.citationHu Jianguo, Zhou Jiansheng, Li Xingwu, Wang Fengchao, Lü Hezuo. Schwann cells promote neurite outgrowth of dorsal root ganglion neurons through secretion of nerve growth factor. Indian Journal of Experimental Biology. 2011 Mar; 49(3): 177-182.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/145112
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/11112en_US
dc.subjectDorsal root gangliaen_US
dc.subjectNerve growth factoren_US
dc.subjectNeurite outgrowthen_US
dc.subjectSchwann cellsen_US
dc.titleSchwann cells promote neurite outgrowth of dorsal root ganglion neurons through secretion of nerve growth factor.en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijeb2011v49n3p177.pdf
Size:
307.03 KB
Format:
Adobe Portable Document Format
Description:
Journal article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Indian Journal of Experimental Biology