Comparison of blood loss in total knee replacement surgery with and without tranexamic acid: a prospective, time framed and observational analytical study

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dc.contributor.authorMandal, S.en_US
dc.contributor.authorChatterjee, B. D.en_US
dc.contributor.authorKar, A.en_US
dc.contributor.authorAgarwal, S.en_US
dc.date.accessioned2024-09-24T06:59:07Z
dc.date.available2024-09-24T06:59:07Z
dc.date.issued2024-06
dc.description.abstractBackground: Total knee replacement is one of the common orthopaedic procedures performed worldwide. Blood transfusion is one of the major requirements in TKR procedure due to the amount of blood loss during and after the procedure. We carried out a prospective study to determine the efficacy of tranexamic acid in controlling blood loss during TKR procedure. Methods: Study was conducted at a tertiary care centre, involving cases operated by a single surgeon. Study included 140 patients undergoing primary TKR for advance degenerative disease of knee and were divided into two groups of 70 each, one group that received tranexamic acid before surgery and another group that did not receive tranexamic acid before surgery. Patient with allergy to the drug, hepato/renal dysfunction, DVT, abnormal PT and INR were not included. Tranexamic acid was given intravenously as well as intra-articular. Results: Pre-operative haemoglobin ranged from 10.2 gm% to 14.4 gm% in the group getting tranexamic acid and from 10% to 14 % in the group not getting tranexamic acid. Post operatively haemoglobin varied from 8.4 gm% to 12.8 gm% in Group 1 and from 7.8 gm% to 12 gm% in Group 2. Difference of mean post-operative Hb (p=0.0045) and PCV (p=0.0024) in two groups was statistically significant. Conclusions: We concluded that administration of tranexamic acid reduces the blood loss as well as need of blood transfusion in a patient undergoing total knee replacement.en_US
dc.identifier.affiliationsDepartment of Orthopaedics, Apollo Gleneagles Hospitals, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsDepartment of Orthopaedics, Apollo Gleneagles Hospitals, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsDepartment of Orthopaedics, Apollo Gleneagles Hospitals, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsDepartment of Orthopaedics, Geetanjali Medical College & Hospital, Udaipur, Rajasthan, Indiaen_US
dc.identifier.citationMandal S., Chatterjee B. D., Kar A., Agarwal S.. Comparison of blood loss in total knee replacement surgery with and without tranexamic acid: a prospective, time framed and observational analytical study. International Journal of Community Medicine and Public Health. 2024 Jun; 11(6): 2285-2290en_US
dc.identifier.issn2394-6032
dc.identifier.issn2394-6040
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/228122
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber6en_US
dc.relation.volume11en_US
dc.source.urihttps://doi.org/10.18203/2394-6040.ijcmph20241486en_US
dc.subjectBlood lossen_US
dc.subjectBlood transfusionen_US
dc.subjectHaemoglobinen_US
dc.subjectTotal knee replacementen_US
dc.subjectTranexamic aciden_US
dc.titleComparison of blood loss in total knee replacement surgery with and without tranexamic acid: a prospective, time framed and observational analytical studyen_US
dc.typeJournal Articleen_US
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