Comparative Study Of The Serum Tissue Plasminogen Activator(T朠a) Levels In Diabetic Patient With And Without Foot Ulcer.
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Date
2024-01
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Indian Society for Health and Advanced Research
Abstract
Background: Diabetic foot ulcer is associated with signi?cant microangiopathy which causes damage to the vascular endothelial cells leading to increased risk of thrombus formation along with impaired process of ?brinolysis. tPA is the most important part of the ?brinolytic system. It has been proven that the level of tPA in the blood re?ects ?brinolytic activity. Hence t-PA levels can be used to identify patients who have microangiopathy and are at risk of developing diabetic foot ulcer To compare the. Objective: concentration levels of serum tissue plasminogen activator (t-PA) levels in Diabetic patients with and without foot ulcer. Materials and methods: This study was conducted in the Department of General Surgery during the period October 2017 to May 2019. Serum Tissue plasminogen activator (tPA) levels in Diabetic patients with and without foot ulcer were assessed and compared. All the demographic parameters studied were also compared with mean tPA and their signi?cance were analyzed. Results: A total of 85 patients with Diabetic foot ulcer and 85 Diabetic patients without foot ulcer were recruited in the study. Median tPA levels (ng/ml) in a diabetic patients with and without foot ulcer was 3.7 and 4.6 with a statistical signi?cance (p value=0.005). Mean tPA levels in patients who presented with and without gangrene among ulcer group was 3.17�05 and 4.52�69 respectively(p value<0.001). Mean tPA levels in ulcer group who had Wagner's grade of ?2 and >2 were 5.87�79 and 3.51�09 respectively. (p value<0.001). Tissue plasminogen activator (t-PA) concentration is signi?cantly lowerConclusions: in diabetic patients with foot ulcer. Lower concentration of t-PA is associated with microangiopathy complications like foot gangrene and higher Wagner's grade
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Keywords
Diabetic Foot, Tissue Plasminogen Activator, Microangiopathy
Citation
T P Elamurugan, Saini Abhishek . Comparative Study Of The Serum Tissue Plasminogen Activator(T朠a) Levels In Diabetic Patient With And Without Foot Ulcer. . Indian Journal Of Applied Research. 2024 Jan; 14(1): 32-34