Expanding horizons of anticoagulant therapy: Dabigatran etexilate a novel oral anticoagulant.

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dc.contributor.authorJadhav, Pradeep
dc.contributor.authorRay, Ipseeta
dc.contributor.authorVieira, Alfven
dc.contributor.authorGhanekar, Jaishree
dc.contributor.authorDeshmukh, Yeshwant A
dc.date.accessioned2014-12-17T07:13:02Z
dc.date.available2014-12-17T07:13:02Z
dc.date.issued2013-09
dc.description.abstractThrombo-embolic disease is a major challenging clinical problem associated with significant mortality and morbidity. Anticoagulation with the existing heparin products and vitamin K antagonist (VKA) anticoagulants are still the mainstay of management. However, due to the risk of bleeding and well-documented drawbacks, the quest for a novel oral anticoagulant has led to the clinical development of dabigatran etexilate. Dabigatran etexilate is a direct thrombin (IIa) inhibitor which has recently been approved in India for prevention of venous thromboembolic events (VTE) in patients who have undergone major orthopaedic (total knee or hip replacement) surgery and for prevention of stroke, systemic embolism and reduction of vascular mortality in adult patients with atrial fibrillation. Thus dabigatran etexilate is a promising alternative to the current heparin products and VKAs in patients who require long-term oral anticoagulation.en_US
dc.identifier.citationJadhav Pradeep, Ray Ipseeta, Vieira Alfven, Ghanekar Jaishree, Deshmukh Yeshwant A. Expanding horizons of anticoagulant therapy: Dabigatran etexilate a novel oral anticoagulant. International Journal of Basic & Clinical Pharmacology. 2013 Sep-Oct; 2(5): 663-667.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/153972
dc.language.isoenen_US
dc.source.urihttps://www.ijbcp.com/?mno=42265en_US
dc.subjectDabigatran etexilateen_US
dc.subjectDirect thrombin inhibitoren_US
dc.subjectNovel anticoagulanten_US
dc.subjectStroke preventionen_US
dc.subjectAtrial fibrillationen_US
dc.subjectVenous thromboembolismen_US
dc.subjectOrthopaedic surgeryen_US
dc.titleExpanding horizons of anticoagulant therapy: Dabigatran etexilate a novel oral anticoagulant.en_US
dc.typeArticleen_US
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