Detection of mutagenicity in cervico-vaginal secretions--a plausible risk factor for cervical cancer.

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dc.contributor.authorParashari, Aen_US
dc.contributor.authorGupta, M Men_US
dc.contributor.authorSingh, Ven_US
dc.contributor.authorBhadola, Pen_US
dc.contributor.authorLuthra, U Ken_US
dc.date.accessioned2009-05-28T15:53:40Z
dc.date.available2009-05-28T15:53:40Z
dc.date.issued1990-07-01en_US
dc.description.abstractThe cervico-vaginal secretions from 51 women with various grades of dysplastic lesions of uterine cervix were assessed for mutagenic potential by Ames test using histidine deficient mutant strain of Salmonella typhimurium TA-98: with S-9 mix. Twenty three per cent of samples from women with cervical dysplasia were found significantly positive (P less than 0.001) for mutagenic activity compared to 3% positive from control. The frequency of mutagenic secretions detected were almost uniform, irrespective of the severity of cervical lesions. None of cervico-vaginal secretions, positive for mutagenicity could revert the tester strain when tested in absence of S-9 mix (liver microsomal enzymes). This indicates that mutagens in cervico-vaginal secretions are effective only when activated enzymatically.en_US
dc.description.affiliationDivision of Immunology & Virology, Maulana Azad Medical College Campus, New Delhi, India.en_US
dc.identifier.citationParashari A, Gupta MM, Singh V, Bhadola P, Luthra UK. Detection of mutagenicity in cervico-vaginal secretions--a plausible risk factor for cervical cancer. Indian Journal of Experimental Biology. 1990 Jul; 28(7): 601-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/62549
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiotransformationen_US
dc.subject.meshCervix Mucus --chemistryen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMutagenicity Testsen_US
dc.subject.meshMutagens --analysisen_US
dc.subject.meshRatsen_US
dc.subject.meshSalmonella typhimurium --drug effectsen_US
dc.subject.meshUterine Cervical Dysplasia --metabolismen_US
dc.titleDetection of mutagenicity in cervico-vaginal secretions--a plausible risk factor for cervical cancer.en_US
dc.typeJournal Articleen_US
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