Case of angioimmunoblastic T-cell lymphoma presenting as peripheral and bone marrow plasmacytosis: A diagnostic conundrum

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dc.contributor.authorGupta, Deepikaen_US
dc.contributor.authorJaine, Nagarjun S.en_US
dc.contributor.authorBairwa, Sandeep K.en_US
dc.contributor.authorThirunavukkarasu, Balamuruganen_US
dc.contributor.authorVishwajeet, Vikarnen_US
dc.contributor.authorPurohit, Abhishek H. L.en_US
dc.date.accessioned2025-05-09T09:57:04Z
dc.date.available2025-05-09T09:57:04Z
dc.date.issued2024-06
dc.description.abstractAngioimmunoblastic T?cell lymphoma (AITL), a subtype of peripheral T?cell lymphoma (PTCL), is associated with unique clinical, morphological, and immunohistochemical features. The peripheral circulation might show presence of an occasional reactive plasma cell but significant plasmacytosis masquerading as plasma cell leukemia is rare. We report a case of AITL in a 42?year?old male, who presented with two?month history of generalized lymphadenopathy. On investigations, he had hypergammaglobulinemia and plasmacytosis in the peripheral blood and bone marrow masquerading as plasma cell leukemia. Immunohistochemistry and serum protein electrophoresis revealed polyclonal nature of plasma cells. Diagnosis of AITL was made on cervical lymph node biopsy. This case highlights the diagnostic challenge faced due to heterogeneity in the clinical presentation and pathological findings and to alert the clinician so that timely accurate diagnosis can be made to initiate the treatment.en_US
dc.identifier.affiliationsDepartment of Pathology and Lab Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology and Lab Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, Indiaen_US
dc.identifier.affiliationsDepartment of Medical Oncology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology and Lab Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology and Lab Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology and Lab Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, Indiaen_US
dc.identifier.citationGupta Deepika, Jaine Nagarjun S., Bairwa Sandeep K., Thirunavukkarasu Balamurugan, Vishwajeet Vikarn, Purohit Abhishek H. L. . Case of angioimmunoblastic T-cell lymphoma presenting as peripheral and bone marrow plasmacytosis: A diagnostic conundrum. Indian Journal of Pathology & Microbiology. 2024 Jun; 67(2): 452-455en_US
dc.identifier.issn0377-4929
dc.identifier.issn0974-5130
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/245466
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber2en_US
dc.relation.volume67en_US
dc.source.urihttps://doi.org/10.4103/ijpm.ijpm_277_22en_US
dc.subjectAngioimmunoblastic T?cell lymphomaen_US
dc.subjectperipheral blooden_US
dc.subjectplasmacytosisen_US
dc.titleCase of angioimmunoblastic T-cell lymphoma presenting as peripheral and bone marrow plasmacytosis: A diagnostic conundrumen_US
dc.typeJournal Articleen_US
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