Case of angioimmunoblastic T-cell lymphoma presenting as peripheral and bone marrow plasmacytosis: A diagnostic conundrum
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Date
2024-06
Journal Title
Journal ISSN
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Publisher
Wolters Kluwer – Medknow
Abstract
Angioimmunoblastic T?cell lymphoma (AITL), a subtype of peripheral T?cell lymphoma (PTCL), is associated with unique clinical, morphological, and immunohistochemical features. The peripheral circulation might show presence of an occasional reactive plasma cell but significant plasmacytosis masquerading as plasma cell leukemia is rare. We report a case of AITL in a 42?year?old male, who presented with two?month history of generalized lymphadenopathy. On investigations, he had hypergammaglobulinemia and plasmacytosis in the peripheral blood and bone marrow masquerading as plasma cell leukemia. Immunohistochemistry and serum protein electrophoresis revealed polyclonal nature of plasma cells. Diagnosis of AITL was made on cervical lymph node biopsy. This case highlights the diagnostic challenge faced due to heterogeneity in the clinical presentation and pathological findings and to alert the clinician so that timely accurate diagnosis can be made to initiate the treatment.
Description
Keywords
Angioimmunoblastic T?cell lymphoma, peripheral blood, plasmacytosis
Citation
Gupta Deepika, Jaine Nagarjun S., Bairwa Sandeep K., Thirunavukkarasu Balamurugan, Vishwajeet Vikarn, Purohit Abhishek H. L. . Case of angioimmunoblastic T-cell lymphoma presenting as peripheral and bone marrow plasmacytosis: A diagnostic conundrum. Indian Journal of Pathology & Microbiology. 2024 Jun; 67(2): 452-455