Hepatoprotective potential of isolated flavonoids from Trapa natans L. against the paracetamol induced oxidative stress in rats

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dc.contributor.authorMajee, Chandanaen_US
dc.contributor.authorMazumde, Rupaen_US
dc.contributor.authorChoudhary, Alka Nen_US
dc.date.accessioned2023-08-09T06:20:55Z
dc.date.available2023-08-09T06:20:55Z
dc.date.issued2022-12
dc.description.abstractOverdose of paracetamol causes liver toxicity, due to oxidative stress by the reactive oxygen species (ROS) that increases the levels of ALT and AST, and reduces the level of the antioxidant enzymes. Flavonoids are a source of natural antioxidants that assist in neutralization of ROS. Several studies have suggested that flavonoids can help protect the liver. The Water Chestnut, Trapa natans L. plants have long been used in the traditional system of medicine and possess considerable antioxidant potential. In this study, we tried to isolate flavonoids from T. natans L. and evaluate the hepatoprotective potential of the isolated compound. We isolated flavonoids from the extract of the aerial part of plant and characterized by UV, IR, NMR and Mass spectroscopy. The isolated flavonoid was induced orally once a day (30 mg/kg). The test drug (isolated compound) could lower the elevated levels of serum enzymes such as glutamate oxaloacetate transaminase (AST), serum glutamate pyruvate transaminase (ALT), alkaline phosphatase (ALP) and total bilirubin. Silymarin (30 mg/kg) was taken as a standard drug that exhibits significant hepatoprotective activity against the paracetamol induced hepatotoxicity model in Wistar albino rats. The histopathological study of rat liver also strengthens biochemical evaluation analysis. Based on the experimental results, it can be concluded that the isolated flavonoids act as hepatoprotective agents in rats.en_US
dc.identifier.affiliationsDepartment of Pharmaceutical Chemistry, Noida Institute of Engineering & Technology (Pharmacy Institute), 19 Knowledge Park II, Institutional Area, Greater Noida – 201 306, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Chemistry, Shri Guru Ram Rai University, Dehrakhas, Patel Nagar, Dehradun - 248 001, Uttarakhand, Indiaen_US
dc.identifier.citationMajee Chandana, Mazumde Rupa, Choudhary Alka N. Hepatoprotective potential of isolated flavonoids from Trapa natans L. against the paracetamol induced oxidative stress in rats. Indian Journal of Experimental Biology. 2022 Dec; 60(12): 910-917en_US
dc.identifier.issn0975-1009
dc.identifier.issn0019-5189
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/222561
dc.languageenen_US
dc.publisherCSIR-NIScPRen_US
dc.relation.issuenumber12en_US
dc.relation.volume60en_US
dc.source.urihttps://doi.org/10.56042/ijeb.v60i12.55735en_US
dc.subjectAntioxidanten_US
dc.subjectLiver toxicityen_US
dc.subjectReactive oxygen speciesen_US
dc.subjectWater Chestnuten_US
dc.titleHepatoprotective potential of isolated flavonoids from Trapa natans L. against the paracetamol induced oxidative stress in ratsen_US
dc.typeJournal Articleen_US
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