Effect of drugs influencing synthesis of prostaglandins on haloperidol-induced catalepsy in rats.

Simple item page
dc.contributor.authorBala Lall, Sen_US
dc.contributor.authorTekur, Uen_US
dc.contributor.authorSen, Pen_US
dc.date.accessioned1984-07-01en_US
dc.date.accessioned2009-06-01T06:32:15Z
dc.date.available1984-07-01en_US
dc.date.available2009-06-01T06:32:15Z
dc.date.issued1984-07-01en_US
dc.description.abstractRats pretreated with prostaglandin synthesis stimulators, phenoxymethyl penicillin (2, 4 and 8 mg/kg, ip) and levamisole (2.5, 5 and 10 mg/kg, ip) showed a dose related potentiation of catalepsy after subthreshold doses of haloperidol (0.1 mg/kg, ip). Pretreatment with prostaglandin synthesis inhibitors paracetamol and indomethacin exhibited significant inhibition of catalepsy at lower doses (2.5, 6, 10 and 15 mg/kg, ip). However, this antagonism was paradoxically less at higher dose levels (20 and 30 mg/kg, ip). The data suggest neuromodulatory contribution of prostaglandins in neuroleptic-induced catalepsy.en_US
dc.identifier.citationBala Lall S, Tekur U, Sen P. Effect of drugs influencing synthesis of prostaglandins on haloperidol-induced catalepsy in rats. Indian Journal of Physiology and Pharmacology. 1984 Jul-Sep; 28(3): 219-22en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/107462
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAcetaminophen --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCatalepsy --chemically induceden_US
dc.subject.meshHaloperidolen_US
dc.subject.meshHumansen_US
dc.subject.meshIndomethacin --pharmacologyen_US
dc.subject.meshLevamisole --pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshPenicillin V --pharmacologyen_US
dc.subject.meshProstaglandins --biosynthesisen_US
dc.subject.meshRatsen_US
dc.titleEffect of drugs influencing synthesis of prostaglandins on haloperidol-induced catalepsy in rats.en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Physiology and Pharmacology