Effect of drugs influencing synthesis of prostaglandins on haloperidol-induced catalepsy in rats.
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1984-07-01
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Rats pretreated with prostaglandin synthesis stimulators, phenoxymethyl penicillin (2, 4 and 8 mg/kg, ip) and levamisole (2.5, 5 and 10 mg/kg, ip) showed a dose related potentiation of catalepsy after subthreshold doses of haloperidol (0.1 mg/kg, ip). Pretreatment with prostaglandin synthesis inhibitors paracetamol and indomethacin exhibited significant inhibition of catalepsy at lower doses (2.5, 6, 10 and 15 mg/kg, ip). However, this antagonism was paradoxically less at higher dose levels (20 and 30 mg/kg, ip). The data suggest neuromodulatory contribution of prostaglandins in neuroleptic-induced catalepsy.
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Bala Lall S, Tekur U, Sen P. Effect of drugs influencing synthesis of prostaglandins on haloperidol-induced catalepsy in rats. Indian Journal of Physiology and Pharmacology. 1984 Jul-Sep; 28(3): 219-22