Cymbopogon citratus Stapf (DC) Extract Ameliorates Atherogenic Cardiovascular Risk in Diabetes-Induced Dyslipidemia in Rats.

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dc.contributor.authorEkpenyong, Christopher E
dc.contributor.authorDavies, Koofreh
dc.contributor.authorAntai, Ekaette Etim
dc.date.accessioned2016-03-09T11:14:04Z
dc.date.available2016-03-09T11:14:04Z
dc.date.issued2014-10-01
dc.description.abstractAims: Diabetic dyslipidemia is a recognized risk factor for coronary heart disease (CHD). Plant medicinal agents such as Cymbopogon citratus (C. citratus) have shown potential as alternative therapies for reducing cardiovascular risk factors. The aim of this study was to investigate the effect of C. citratus leaf extract on the atherogenic index of plasma (AIP) in diabetic dyslipidemic rats (n=35). Materials and Methods: A C. citratus extract was prepared by ethanol extraction of leaf material. Rats were divided into seven groups (n=5) as follows: (a) Normal diet control, (b) Hyperlipidemic diet (HLD) control, (c) HLD + 65mg/kg streptozotocin (STZ) control (d) HLD + STZ + 250mg/kg C. citratus extract (CCE), (e) HLD + STZ + 500mg/kg CCE, (f) HLD + STZ + 1000mg/kg CCE, and (g) HLD + STZ + 5mg/kg atorvastatin + 600μg/g glibenclamide. Animals were treated with HLD for 14 days and then injected intraperitoneally with 65mg/kg STZ. Confirmed diabetic dyslipidemic animals were treated intragastrically with CCE at doses of 250, 500, and 1000mg/kg, with 5mg/kg atorvastatin, and with 600μg/g glibenclamide for 30 days. Results: The extract, which tested positive for tannins, saponins, alkaloids, flavonoids, etc. lowered fasting blood glucose and glycosylated hemoglobin levels, and dose- dependently decreased the serum levels of T-chol, LDL, VLDL, and b-HMG-CoA reductase, while simultaneously increasing HDL levels. The AIP was lowered in a dosedependent manner by 33, 43.7, and 52.4% in groups treated with 250, 500, and 1000 mg/kg of CCE respectively. Conclusion: The results indicate that the C. citratus extract had an ameliorative effect on hyperglycemia, hyperlipidemia, obesity, and atherogenic index of plasma.en_US
dc.identifier.citationEkpenyong Christopher E, Davies Koofreh , Antai Ekaette Etim. Cymbopogon citratus Stapf (DC) Extract Ameliorates Atherogenic Cardiovascular Risk in Diabetes-Induced Dyslipidemia in Rats.British Journal of Medicine and Medical Research. 2014 Oct; 4(28): 4695-4709.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/175544
dc.language.isoenen_US
dc.source.urihttps://sciencedomain.org/abstract/5026en_US
dc.subjectCymbopogon citratus stapfen_US
dc.subjectdiabetesen_US
dc.subjectdyslipidemiaen_US
dc.subjectatherogenic risken_US
dc.subjectratsen_US
dc.titleCymbopogon citratus Stapf (DC) Extract Ameliorates Atherogenic Cardiovascular Risk in Diabetes-Induced Dyslipidemia in Rats.en_US
dc.typeArticleen_US
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